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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/24183

Title: Controlling the Release of Indomethacin from Glass Solutions Layered with a Rate Controlling Membrane Using Fluid-Bed Processing. Part 2: The Influence of Formulation Parameters on Drug Release
Authors: Dereyrnaker, Aswin
Pelgrims, Jirka
Engelen, Frederik
Adriaensens, Peter
Van den Mooter, Guy
Issue Date: 2017
Publisher: AMER CHEMICAL SOC
Citation: MOLECULAR PHARMACEUTICS, 14(4), p. 974-983
Abstract: This study aimed to investigate the pharmaceutical performance of an indomethacin polyvinylpyrrolidone (PVP) glass solution applied using fluid bed processing as a layer on inert sucrose spheres and subsequently top-coated with a release rate controlling membrane consisting of either ethyl cellulose or Eudragit RL. The implications of the addition of a pore former (PVP) and the coating medium (ethanol or water) on the diffusion and release behavior were also considered. In addition, the role of a charge interaction between drug and controlled release polymer on the release was investigated. Diffusion experiments pointed to the influence of pore former concentration, rate controlling polymer type, and coating solvent on the permeability of the controlled release membranes. This can be translated to drug release tests, which show the potential of diffusion tests as a preliminary screening test and that diffusion is the main factor influencing release. Drug release tests also showed the effect of coating layer thickness. A charge interaction between INDO and ERI, was demonstrated, but this had no negative effect on drug release. The higher diffusion and release observed in ERL-based rate controlling membranes was explained by a higher hydrophilicity, compared to EC.
Notes: [Dereyrnaker, Aswin; Pelgrims, Jirka; Engelen, Frederik; Van den Mooter, Guy] Katholieke Univ Leuven, Drug Delivery & Disposit, Campus Gasthuisberg O&N2,Herestr 49,Box 921, B-3000 Leuven, Belgium. [Adriaensens, Peter] Hasselt Univ, Inst Mat Res, Appl & Analyt Chem, Campus Diepenbeek,Agoralaan 1 Bldg D, B-3590 Diepenbeek, Belgium.
URI: http://hdl.handle.net/1942/24183
DOI: 10.1021/acs.molpharmaceut.6b01024
ISI #: 000398426100002
ISSN: 1543-8384
Category: A1
Type: Journal Contribution
Appears in Collections: Research publications

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