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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/24181

Title: The use of incretins and fractures - a meta-analysis on population-based real life data
Authors: Driessen, Johanna H. M.
de Vries, Frank
van Onzenoort, Hein
Harvey, Nicholas C.
Neef, Cees
Van den Bergh, Joop
Vestergaard, Peter
Henry, Ronald M. A.
Issue Date: 2017
Publisher: WILEY
Abstract: The aim of the present study was to estimate the effect of incretins on fracture risk in the real-world situation by meta-analysis of the available population-based cohort data. Pubmed and Embase were searched for original articles investigating use of incretin agents, and fracture risk up to December 2015. Adjusted results were extracted and pooled by use of generic inverse variance methods, assuming a random-effects model. Neither current dipeptidyl peptidase 4-inhibitor use nor current glucagon-like peptide 1 receptor agonist use was associated with a decreased risk of fracture: pooled relative risk (pooled RR [95% confidence interval]: 1.02 [0.91-1.13] and 1.03 [0.87-1.22]), respectively. This meta-analysis demonstrated that current use of incretin agents, was not associated with decreased fracture risk. Our findings show the value of representative real-world populations, and the risks associated with suggesting benefits for medications on the basis of safety reporting in randomized controlled trials.
Notes: [Driessen, Johanna H. M.; de Vries, Frank] Utrecht Inst Pharmaceut Sci, Div Pharmacoepidemiol & Clin Pharmacol, Utrecht, Netherlands. [Driessen, Johanna H. M.; de Vries, Frank; Neef, Cees] Maastricht Univ, Care & Publ Hlth Res Inst CAPHRI, Med Ctr, Maastricht, Netherlands. [Driessen, Johanna H. M.; de Vries, Frank; van Onzenoort, Hein; Neef, Cees] Maastricht Univ, Dept Clin Pharm & Toxicol, Med Ctr, Maastricht, Netherlands. [de Vries, Frank; Harvey, Nicholas C.] Univ Southampton, MRC, Lifecourse Epidemiol Unit, Southampton, Hants, England. [van Onzenoort, Hein] Radboud Univ Nijmegen, Dept Pharm, Med Ctr, Nijmegen, Netherlands. [van den Bergh, Joop P. W.] Maastricht Univ, Dept Internal Med, Med Ctr, Maastricht, Netherlands. [van den Bergh, Joop P. W.] Univ Hasselt, Biomed Res Inst, Hasselt, Belgium. [Vestergaard, Peter] Aalborg Univ, Dept Clin Med, Aalborg, Denmark. [Vestergaard, Peter] Aalborg Univ Hosp, Dept Endocrinol, Aalborg, Denmark. [Henry, Ronald M. A.] Maastricht Univ, Dept Med, Med Ctr, Maastricht, Netherlands. [Henry, Ronald M. A.] Maastricht Univ, Cardiovasc Res Inst, Med Ctr, Maastricht, Netherlands.
URI: http://hdl.handle.net/1942/24181
DOI: 10.1111/bcp.13167
ISI #: 000397577800022
ISSN: 0306-5251
Category: A1
Type: Journal Contribution
Appears in Collections: Research publications

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