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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/24175

Title: Perfusion of the uterine junctional zone in nulliparous and primiparous women assessed by DCE-MRI, as a function of menstrual cycle and hormonal contraception
Authors: Meylaerts, L. J.
Wijnen, L.
Bazot, M.
Grieten, M.
Ombelet, Willem
Vandersteen, Marjan
Issue Date: 2017
Citation: MAGNETIC RESONANCE IMAGING, 38, p. 101-111
Abstract: Purpose: To evaluate the perfusion parameters of inner and outer myometrium in healthy nulliparous and primiparous women who are and who are not currently using hormonal contraceptives by means of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI). Material and methods: We performed pelvic 1.5 T DCE-MRI on 98 women: 18 nulliparous non-users, 30 nulliparous users, 12 primiparous non-users and 38 primiparous users of hormonal contraception (mean age respectively 26.4, 25.8, 3023 and 28.18 years). The nulliparous non-users underwent DCE-MRI investigations during their follicular, ovulatory and luteal phase. Perfusion parameters (iAUC/volume, Ktrans, Kep and Ve) were assessed in the anterior and posterior junctional zone (JZ), outer myometrium and cervix. Results: In nulliparous non-users, the mean Ktrans and iAUC/volume showed a decrease from follicular to luteal phase (0.82 vs 0.55 min(-1) for Ktrans, p = 0/027 and 1.28 vs 0.68 for iAUC/volume, p < 0.001). The anterior JZ demonstrated lower Ktrans (p = 0.050) and higher Kep (p = 0.012), in nulliparous non-users, lower Ktrans in nulliparous users (p < 0.001) and lower Ve in primiparous users (p = 0.012) than the anterior outer myometrium. Ktrans at the anterior and posterior JZ wall in nulliparous users was lower than in non-users (p = 0.001 and p = 0.013) and Ve at the anterior JZ wall in primiparous users was lower than in non-users (p = 0.044). Conclusion: This study provides data on normal perfusion parameters of inner and outer myometrium, which may be potentially useful in assisted reproductive therapy. (C) 2016 Elsevier Inc All rights reserved.
Notes: [Meylaerts, L. J.; Wijnen, L.; Grieten, M.] Ziekenhuis Oost Limburg, Dept Med Imaging, Schiepse Bos 6, B-3600 Genk, Belgium. [Bazot, M.] Hop Tenon, Dept Radiol, Paris, France. [Ombelet, W.] Ziekenhuis Oost Limburg, Dept Obstet & Gynecol, Genk, Belgium. [Wijnen, L.; Vandersteen, M.] Hasselt Univ, Fac Med & Biomed, Diepenbeek, Belgium.
URI: http://hdl.handle.net/1942/24175
DOI: 10.1016/j.mri.2016.12.026
ISI #: 000398008700015
ISSN: 0730-725X
Category: A1
Type: Journal Contribution
Validation: ecoom, 2018
Appears in Collections: Research publications

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