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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/24159

Title: An association of particulate air pollution and traffic exposure with mortality after lung transplantation in Europe
Authors: Ruttens, David
Verleden, Stijn E.
Bijnens, Esmée M.
Winckelmans, Ellen
Gottlieb, Jens
Warnecke, Gregor
Meloni, Federica
Morosini, Monica
Van Der Bij, Wim
Verschuuren, Erik A.
Sommerwerck, Urte
Weinreich, Gerhard
Kamler, Markus
Roman, Antonio
Gomez-Olles, Susana
Berastegui, Cristina
Benden, Christian
Holm, AreMartin
Iversen, Martin
Schultz, Hans Henrik
Luijk, Bart
Oudijk, Erik-Jan
Erp, Johanna M. Kwakkel-van
Jaksch, Peter
Klepetko, Walter
Kneidinger, Nikolaus
Neurohr, Claus
Corris, Paul
Fisher, Andrew J.
Lordan, James
Meachery, Gerard
Piloni, Davide
Vandermeulen, Elly
Bellon, Hannelore
Hoffmann, Barbara
Vienneau, Danielle
Hoek, Gerard
de Hoogh, Kees
Nemery, Benoit
Verleden, Geert M.
Vos, Robin
Nawrot, Tim S.
Vanaudenaerde, Bart M.
Issue Date: 2017
Publisher: EUROPEAN RESPIRATORY SOC JOURNALS LTD
Citation: EUROPEAN RESPIRATORY JOURNAL, 49(1), p. 1-8 (Art N° UNSP 1600484)
Abstract: Air pollution from road traffic is a serious health risk, especially for susceptible individuals. Single-centre studies showed an association with chronic lung allograft dysfunction (CLAD) and survival after lung transplantation, but there are no large studies. 13 lung transplant centres in 10 European countries created a cohort of 5707 patients. For each patient, we quantified residential particulate matter with aerodynamic diameter. 10 mu m (PM10) by land use regression models, and the traffic exposure by quantifying total road length within buffer zones around the home addresses of patients and distance to a major road or freeway. After correction for macrolide use, we found associations between air pollution variables and CLAD/ mortality. Given the important interaction with macrolides, we stratified according to macrolide use. No associations were observed in 2151 patients taking macrolides. However, in 3556 patients not taking macrolides, mortality was associated with PM10 (hazard ratio 1.081, 95% CI 1.000-1.167); similarly, CLAD and mortality were associated with road lengths in buffers of 200-1000 and 100-500 m, respectively (hazard ratio 1.0851.130). Sensitivity analyses for various possible confounders confirmed the robustness of these associations. Long-term residential air pollution and traffic exposure were associated with CLAD and survival after lung transplantation, but only in patients not taking macrolides.
Notes: [Ruttens, David; Verleden, Stijn E.; Piloni, Davide; Vandermeulen, Elly; Bellon, Hannelore; Nemery, Benoit; Verleden, Geert M.; Vos, Robin; Vanaudenaerde, Bart M.] Katholieke Univ Leuven, Leuven, Belgium. [Bijnens, Esmee M.; Winckelmans, Ellen; Nawrot, Tims.] Hasselt Univ, Hasselt, Belgium. [Gottlieb, Jens; Warnecke, Gregor] Hannover Med Sch, Hannover, Germany. [Meloni, Federica; Morosini, Monica; Piloni, Davide] Univ Pavia, Pavia, Italy. [Van Der Bij, Wim; Verschuuren, Erik A.] Univ Groningen, Univ Med Ctr Groningen, Groningen, Netherlands. [Sommerwerck, Urte; Weinreich, Gerhard; Kamler, Markus] Univ Duisburg Essen, Univ Hosp Essen, Ruhrlandklin, Essen, Germany. [Roman, Antonio; Gomez-Olles, Susana; Berastegui, Cristina] Univ Autonoma Barcelona, Hosp Vall Hebron, Barcelona, Spain. [Roman, Antonio; Gomez-Olles, Susana] CIBER Enfermedades Resp CIBERES, Barcelona, Spain. [Benden, Christian] Univ Zurich Hosp, Zurich, Switzerland. [Holm, AreMartin] Univ Oslo, Oslo, Norway. [Holm, AreMartin] Oslo Univ Hosp, Dept Resp Med, Oslo, Norway. [Iversen, Martin; Schultz, Hans Henrik] Univ Copenhagen Hosp, Rigshosp, Copenhagen, Denmark. [Luijk, Bart; Oudijk, Erik-Jan; Erp, Johanna M. Kwakkel-van; Hoek, Gerard] St Antonius Hosp Nieuwegein, Univ Med Ctr Utrecht, Utrecht, Netherlands. [Jaksch, Peter; Klepetko, Walter] Univ Vienna, Vienna, Austria. [Kneidinger, Nikolaus; Neurohr, Claus] Klinikum Grosshadern LMU, Munich, Germany. [Fisher, Andrew J.; Lordan, James; Meachery, Gerard] Newcastle Univ, Newcastle Upon Tyne, Tyne & Wear, England. [Hoffmann, Barbara] Univ Klinikum Dusseldorf, Dusseldorf, Germany. [Vienneau, Danielle; de Hoogh, Kees] Swiss Trop & Publ Hlth Inst, Basel, Switzerland. [Vienneau, Danielle; de Hoogh, Kees] Univ Basel, Basel, Switzerland.
URI: http://hdl.handle.net/1942/24159
DOI: 10.1183/13993003.00484-2016
ISI #: 000397423500011
ISSN: 0903-1936
Category: A1
Type: Journal Contribution
Appears in Collections: Research publications

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