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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/24152

Title: Dental development in patients with agenesis
Authors: Lebbe, A.
de Llano-Perula, M. Cadenas
Thevissen, P.
Verdonck, A.
Fieuws, Steffen
Willems, Gert
Issue Date: 2017
Publisher: SPRINGER
Citation: INTERNATIONAL JOURNAL OF LEGAL MEDICINE, 131(2), p. 537-546
Abstract: Recent research concerning tooth development and dental agenesis suggests that specific genes are associated with agenesis, and that these genetic factors could also cause delayed dental development of the remaining teeth. The objective of this study was to evaluate whether dental development of patients with agenesis is delayed, compared to a control group. Panoramic radiographs of 1145 patients with dental agenesis were collected (452 males, 693 females) aged 6.2 to 24.8 years. The control group included 2032 panoramic radiographs (977 males, 1055 females) aged 6.0 to 24.4 years. A total of 3177 orthopantomograms were staged according to Demirjian. All left permanent teeth present in the mandible (except third molars) were considered. In order to evaluate the difference between patients with and without agenesis, a developmental score (DS) was calculated. The association between the DS and the number of agenetic teeth was evaluated with a Spearman correlation. Based on the DS, patients with agenesis have a delayed development compared to patients in the control group (p < 0.0001). Within the agenesis group, there is a weak relation between the number of agenetic teeth and the DS: the higher the number of teeth with agenesis, the lower the DS (p < 0.0001 and p = 0.06 for females and males, respectively). The obtained results can be an important factor for treatment planning in patients with dental agenesis. Moreover, the presence of agenesis needs to be taken into account when using age estimation methods based on permanent tooth development.
Notes: [Lebbe, A.; de Llano-Perula, M. Cadenas; Verdonck, A.; Willems, G.] Katholieke Univ Leuven, Dept Oral Hlth Sci Orthodont, Kapucijnenvoer 7, B-3000 Leuven, Belgium. [Lebbe, A.; de Llano-Perula, M. Cadenas; Thevissen, P.; Verdonck, A.; Willems, G.] Univ Hosp Leuven, Dent, Kapucijnenvoer 7, B-3000 Leuven, Belgium. [Thevissen, P.] Katholieke Univ Leuven, Dept Oral Hlth Sci Forens Dent, Kapucijnenvoer 7, B-3000 Leuven, Belgium. [Fieuws, S.] Katholieke Univ Leuven, Interuniv Inst Biostat & Stat Bioinformat, Leuven, Belgium. [Fieuws, S.] Univ Hasselt, Leuven, Belgium.
URI: http://hdl.handle.net/1942/24152
DOI: 10.1007/s00414-016-1450-0
ISI #: 000394378200029
ISSN: 0937-9827
Category: A1
Type: Journal Contribution
Appears in Collections: Research publications

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