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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/24150

Title: Platelet-rich plasma for regeneration of neural feedback pathways around dental implants: a concise review and outlook on future possibilities
Authors: Huang, Yan
Bornstein, Michael M.
Lambrichts, Ivo
Yu, Hai-Yang
Politis, Constantinus
Jacobs, Reinhilde
Issue Date: 2017
Abstract: Along with the development of new materials, advanced medical imaging and surgical techniques, osseointegrated dental implants are considered a successful and constantly evolving treatment modality for the replacement of missing teeth in patients with complete or partial edentulism. The importance of restoring the peripheral neural feedback pathway and thus repairing the lack of periodontal mechanoreceptors after tooth extraction has been highlighted in the literature. Nevertheless, regenerating the nerve fibers and reconstructing the neural feedback pathways around osseointegrated implants remain a challenge. Recent studies have provided evidence that platelet-rich plasma (PRP) therapy is a promising treatment for musculoskeletal injuries. Because of its high biological safety, convenience and usability, PRP therapy has gradually gained popularity in the clinical field. Although much remains to be learned, the growth factors from PRP might play key roles in peripheral nerve repair mechanisms. This review presents known growth factors contributing to the biological efficacy of PRP and illustrates basic and (pre-)clinical evidence regarding the use of PRP and its relevant products in peripheral nerve regeneration. In addition, the potential of local application of PRP for structural and functional recovery of injured peripheral nerves around dental implants is discussed.
Notes: [Huang, Yan; Bornstein, Michael M.; Politis, Constantinus; Jacobs, Reinhilde] Katholieke Univ Leuven, Fac Med, Dept Imaging & Pathol, OMFS IMPATH Res Grp, Leuven, Belgium. [Huang, Yan; Bornstein, Michael M.; Politis, Constantinus; Jacobs, Reinhilde] Univ Hosp Leuven, Dept Oral & Maxillofacial Surg, Leuven, Belgium. [Huang, Yan; Yu, Hai-Yang] Sichuan Univ, West China Hosp Stomatol, Natl Res Ctr Oral Dis, State Key Lab Oral Dis, Chengdu, Peoples R China. [Bornstein, Michael M.] Univ Bern, Dept Oral Surg & Stomatol, Sect Dent Radiol & Stomatol, Bern, Switzerland. [Bornstein, Michael M.] Univ Hong Kong, Prince Philip Dent Hosp, Fac Dent, Appl Oral Sci, Hong Kong, Peoples R China. [Lambrichts, Ivo] Hasselt Univ, Biomed Res Inst, Grp Morphol, Diepenbeek, Belgium.
URI: http://hdl.handle.net/1942/24150
DOI: 10.1038/ijos.2017.1
ISI #: 000397811000001
ISSN: 1674-2818
Category: A1
Type: Journal Contribution
Validation: ecoom, 2018
Appears in Collections: Research publications

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