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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/24141

Title: MicroCT assessment of bone microarchitecture in implant sites reconstructed with autogenous and xenogenous grafts: a pilot study
Authors: Vasconcelos, Karla de Faria
Corpas, Livia dos Santos
da Silveira, Bernardo Mattos
Laperre, Kjell
Padovan, Luis Eduardo
Jacobs, Reinhilde
Luiz de Freitas, Paulo Henrique
Lambrichts, Ivo
Boscolo, Frab Norberto
Issue Date: 2017
Publisher: WILEY
Citation: CLINICAL ORAL IMPLANTS RESEARCH, 28(3), p. 308-313
Abstract: Purpose: To assess bone microarchitecture in maxillary sites grafted with autogenous or xenogenous grafts as well as to demonstrate the usefulness of microCT in dental implant research. Materials and Methods: Samples (n = 12) consisting of titanium fixation screws covered by at least 0.5-1 mm of human bone were obtained from 17 sites grafted with autogenous or xenogenous materials and prepared for microCT scanning and conventional histology. Bone histomorphometric parameters were evaluated in three distinct regions (graft region, transitional region, and native bone region). Three-dimensional (3D) bone-to-implant contact (BIC) calculation was performed using microCT data. Histological sections were used to calculate two-dimensional (2D) BIC percentages, which were compared with values obtained from 2D microCT images. Results: Histomorphometric parameters varied according to the type of graft used, but sites reconstructed with autogenous bone showed higher mean values in general. In autograft samples, indices for parameters such as Tb. Th and Tb. Sp were significantly different when the native bone region was compared to the graft region. While a higher mean 3D BIC was found in the native bone region for both graft materials, significant BIC differences were absent when graft types were compared. The 2D BIC percentages obtained from histological and microCT images were similar. Conclusions: Autografts outperformed the xenogenous material used in this study concerning the histomorphometric parameters assessed. While graft type did not seem to influence 3D BIC, the native bone region showed the highest BIC percentages when compared to the other regions in both graft groups. In addition, 2D BIC ratios were similar regardless of graft material or image source (histological sections x microCT slices). Taken together, our findings suggest that microCT is an effective tool for 2D and 3D histomorphometric and BIC assessments in dental implant research.
Notes: [Vasconcelos, Karla de Faria; Boscolo, Frab Norberto] Univ Estadual Campinas, Piracicaba Dent Sch, Dept Oral Diag, Div Oral Radiol, Sao Paulo, Brazil. [Corpas, Livia dos Santos] Katholieke Univ Leuven, Dept Prosthet Dent Oral Hlth Sci, Fac Med, Leuven, Belgium. [da Silveira, Bernardo Mattos] Brazilian Dent Assoc ABO RJ, Dept Prosthet Dent, Rio De Janeiro, Brazil. [Laperre, Kjell] Bruker Skyscan, Kontich, Belgium. [Padovan, Luis Eduardo] Latin Amer Inst Dent Res & Training ILAPEO, Dept Implant Dent, Curitiba, Parana, Brazil. [Jacobs, Reinhilde] Univ Leuven, OMFS Impath Res Grp, Dept Imaging & Pathol, Fac Med, Leuven, Belgium. [Jacobs, Reinhilde] Leuven Univ Hosp, Dept Maxillofacial Surg, Leuven, Belgium. [Luiz de Freitas, Paulo Henrique] Univ Fed Sergipe, Dept Dent, Lagarto, Brazil. [Lambrichts, Ivo] Hasselt Univ, Biomed Res Inst, Lab Morphol, Diepenbeek, Belgium.
URI: http://hdl.handle.net/1942/24141
DOI: 10.1111/clr.12799
ISI #: 000397311300007
ISSN: 0905-7161
Category: A1
Type: Journal Contribution
Appears in Collections: Research publications

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