Document Server@UHasselt >
Research >
Research publications >

Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/24129

Title: Fornix deep brain stimulation induced long-term spatial memory independent of hippocampal neurogenesis
Authors: Hescham, Sarah
Temel, Yasin
Schipper, Sandra
Lagiere, Melanie
Schonfeld, Lisa-Maria
Blokland, Arjan
Jahanshahi, Ali
Issue Date: 2017
Citation: BRAIN STRUCTURE & FUNCTION, 222(2), p. 1069-1075
Abstract: Deep brain stimulation (DBS) is an established symptomatic treatment modality for movement disorders and constitutes an emerging therapeutic approach for the treatment of memory impairment. In line with this, fornix DBS has shown to ameliorate cognitive decline associated with dementia. Nonetheless, mechanisms mediating clinical effects in demented patients or patients with other neurological disorders are largely unknown. There is evidence that DBS is able to modulate neurophysiological activity in targeted brain regions. We therefore hypothesized that DBS might be able to influence cognitive function via activity-dependent regulation of hippocampal neurogenesis. Using stimulation parameters, which were validated to restore memory loss in a previous behavioral study, we here assessed long-term effects of fornix DBS. To do so, we injected the thymidine analog, 5-bromo-2'-deoxyuridine (BrdU), after DBS and perfused the animals 6.5 weeks later. A week prior to perfusion, memory performance was assessed in the water maze. We found that acute stimulation of the fornix improved spatial memory performance in the water maze when the probe trial was performed 1 h after the last training session. However, no evidence for stimulation-induced neurogenesis was found in fornix DBS rats when compared to sham. Our results suggest that fornix DBS improves memory functions independent of hippocampal neurogenesis, possibly through other mechanisms such as synaptic plasticity and acute neurotransmitter release.
Notes: [Hescham, Sarah; Temel, Yasin; Schipper, Sandra; Lagiere, Melanie; Schonfeld, Lisa-Maria; Jahanshahi, Ali] Maastricht Univ, Dept Neurosci, POB 616, NL-6200 MD Maastricht, Netherlands. [Temel, Yasin] Maastricht Univ, Dept Neurosurg, POB 616, NL-6200 MD Maastricht, Netherlands. [Schipper, Sandra] Maastricht Univ, Dept Neurol, POB 616, NL-6200 MD Maastricht, Netherlands. [Blokland, Arjan] Maastricht Univ, Dept Neuropsychol & Psychopharmacol, POB 616, NL-6200 MD Maastricht, Netherlands. [Schonfeld, Lisa-Maria] Hasselt Univ, Biomed Res Inst BIOMED, Dept Morphol, Hasselt, Belgium. [Hescham, Sarah; Temel, Yasin; Schipper, Sandra; Lagiere, Melanie; Schonfeld, Lisa-Maria; Blokland, Arjan; Jahanshahi, Ali] European Grad Sch Neurosci Euron, Maastricht, Netherlands.
URI: http://hdl.handle.net/1942/24129
DOI: 10.1007/s00429-016-1188-y
ISI #: 000396034300025
ISSN: 1863-2653
Category: A1
Type: Journal Contribution
Appears in Collections: Research publications

Files in This Item:

Description SizeFormat
Published version652.57 kBAdobe PDF

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.