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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/24124

Title: Physicochemical characterizations of functional hybrid liposomal nanocarriers formed using photosensitive lipids
Authors: Pramanik, Sumit Kumar
Losada-Perez, Patricia
Reekmans, Gunter
Carleer, Robert
D'Olieslaeger, Marc
Vanderzande, Dirk
Adriaensens, Peter
Ethirajan, Anitha
Issue Date: 2017
Publisher: NATURE PUBLISHING GROUP
Citation: SCIENTIFIC REPORTS, 7, p. 1-9 (Art N° 46257)
Abstract: With recent advances in the field of diagnostics and theranostics, liposomal technology has secured a fortified position as a potential nanocarrier. Specifically, radiation/photo-sensitive liposomes containing photo-polymerizable cross-linking lipids are intriguing as they can impart the vesicles with highly interesting properties such as response to stimulus and improved shell stability. In this work, 1,2-bis(10,12-tricosadiynoyl)-sn-glycero-3-phosphoethanolamine (DTPE) is used as a photo-polymerizable lipid to form functional hybrid-liposomes as it can form intermolecular cross-linking through the diacetylenic groups. Hybrid-liposomes were formulated using mixtures of DTPE and saturated lipids of different chain lengths (dipalmitoylphosphatidylcholine (DPPC) and dimirystoilphosphatidylcholine (DMPC)) at different molar ratios. The physico-chemical characteristics of the liposomes has been studied before and after UV irradiation using a combination of techniques: DSC, QCM-D and solid-state NMR. The results signify the importance of a subtle modification in alkyl chain length on the phase behavior of the hybrid-liposomes and on the degree of crosslinking in the shell.
Notes: [Pramanik, Sumit Kumar; Losada-Perez, Patricia; Reekmans, Gunter; Carleer, Robert; D'Olieslaeger, Marc; Vanderzande, Dirk; Adriaensens, Peter; Ethirajan, Anitha] Hasselt Univ, Inst Mat Res IMO, Wetenschapspk 1 & Agoralaan D, B-3590 Diepenbeek, Belgium. [Pramanik, Sumit Kumar; Losada-Perez, Patricia; Reekmans, Gunter; Carleer, Robert; D'Olieslaeger, Marc; Vanderzande, Dirk; Adriaensens, Peter; Ethirajan, Anitha] IMEC, Associated Lab IMOMEC, Wetenschapspk 1, B-3590 Diepenbeek, Belgium.
URI: http://hdl.handle.net/1942/24124
DOI: 10.1038/srep46257
ISI #: 000399011400001
ISSN: 2045-2322
Category: A1
Type: Journal Contribution
Appears in Collections: Research publications

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