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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/24120

Title: In vivo evidence for long-term vascular remodeling resulting from chronic cerebral hypoperfusion in mice
Authors: Struys, Tom
Govaerts, Kristof
Oosterlinck, Wouter
Casteels, Cindy
Bronckaers, Annelies
Koole, Michel
Van Laere, Koen
Herijgers, Paul
Lambrichts, Ivo
Himmelreich, Uwe
Dresselaers, Tom
Issue Date: 2017
Publisher: SAGE PUBLICATIONS INC
Citation: JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 37(2), p. 726-739
Abstract: We have characterized both acute and long-term vascular and metabolic effects of unilateral common carotid artery occlusion in mice by in vivo magnetic resonance imaging and positron emission tomography. This common carotid artery occlusion model induces chronic cerebral hypoperfusion and is therefore relevant to both preclinical stroke studies, where it serves as a control condition for a commonly used mouse model of ischemic stroke, and neurodegeneration, as chronic hypoperfusion is causative to cognitive decline. By using perfusion magnetic resonance imaging, we demonstrate that under isoflurane anesthesia, cerebral perfusion levels recover gradually over one month. This recovery is paralleled by an increase in lumen diameter and altered tortuosity of the contralateral internal carotid artery at one year postligation as derived from magnetic resonance angiography data. Under urethane/alpha-chloralose anesthesia, no acute perfusion differences are observed, but the vascular response capacity to hypercapnia is found to be compromised. These hemispheric perfusion alterations are confirmed by water [O-15]-H2O positron emission tomography. Glucose metabolism ([F-18]-FDG positron emission tomography) or white matter organization (diffusion-weighted magnetic resonance imaging) did not show any significant alterations. In conclusion, permanent unilateral common carotid artery occlusion results in acute and long-term vascular remodeling, which may have immediate consequences for animal models of stroke but also vascular dementia.
Notes: [Struys, Tom; Bronckaers, Annelies; Lambrichts, Ivo] Hasselt Univ, Biomed Res Inst, Morphol Res Grp, Hasselt, Belgium. [Govaerts, Kristof; Himmelreich, Uwe; Dresselaers, Tom] Katholieke Univ Leuven, Dept Imaging & Pathol, MoSAIC, Biomed MRI Unit, Leuven, Belgium. [Oosterlinck, Wouter; Herijgers, Paul] Katholieke Univ Leuven, Dept Cardiovasc Sci, Res Unit Expt Cardiac Surg, Leuven, Belgium. [Casteels, Cindy; Koole, Michel; Van Laere, Koen] Katholieke Univ Leuven, Dept Imaging & Pathol, Nucl Med MoSAIC, Leuven, Belgium. [Dresselaers, Tom] Univ Hosp, Radiol, Leuven, Belgium.
URI: http://hdl.handle.net/1942/24120
DOI: 10.1177/0271678X16638349
ISI #: 000393903900028
ISSN: 0271-678X
Category: A1
Type: Journal Contribution
Appears in Collections: Research publications

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