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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/24116

Title: Relapsing-remitting multiple sclerosis patients display an altered lipoprotein profile with dysfunctional HDL
Authors: Jorissen, Winde
Wouters, Elien
Bogie, Jeroen F.
Vanmierlo, Tim
Noben, Jean-Paul
Sviridov, Denis
Hellings, Niels
Somers, Veerle
Valcke, Roland
Vanwijmeersch, Bart
Stinissen, Piet
Mulder, Monique T.
Remaley, Alan T.
Hendriks, Jerome J. A.
Issue Date: 2017
Citation: SCIENTIFIC REPORTS, 7 (Art N° 43410), p. 1-14.
Abstract: Lipoproteins modulate innate and adaptive immune responses. In the chronic inflammatory disease multiple sclerosis (MS), reports on lipoprotein level alterations are inconsistent and it is unclear whether lipoprotein function is affected. Using nuclear magnetic resonance (NMR) spectroscopy, we analysed the lipoprotein profile of relapsing-remitting (RR) MS patients, progressive MS patients and healthy controls (HC). We observed smaller LDL in RRMS patients compared to healthy controls and to progressive MS patients. Furthermore, low-BMI (BMI <= 23 kg/m(2)) RRMS patients show increased levels of small HDL (sHDL), accompanied by larger, triglyceride (TG)-rich VLDL, and a higher lipoprotein insulin resistance (LP-IR) index. These alterations coincide with a reduced serum capacity to accept cholesterol via ATP-binding cassette (ABC) transporter G1, an impaired ability of HDL3 to suppress inflammatory activity of human monocytes, and modifications of HDL3's main protein component ApoA-I. In summary, lipoprotein levels and function are altered in RRMS patients, especially in low-BMI patients, which may contribute to disease progression in these patients.
Notes: [Jorissen, Winde; Wouters, Elien; Bogie, Jeroen F.; Vanmierlo, Tim; Noben, Jean-Paul; Hellings, Niels; Somers, Veerle; Stinissen, Piet; Hendriks, Jerome J. A.] Hasselt Univ, Dept Immunol & Biochem, Biomed, Diepenbeek, Belgium. [Sviridov, Denis; Remaley, Alan T.] NIH, Dept Lab Med, Ctr Clin, Bldg 10, Bethesda, MD 20892 USA. [Valcke, Roland] Hasselt Univ, Fac Sci Mol & Phys Plant Physiol, Diepenbeek, Belgium. [Vanwijmeersch, Bart] Revalidat & MS Ctr, Overpelt, Belgium. [Mulder, Monique T.] Erasmus MC, Dept Vasc & Met Dis, Rotterdam, Netherlands.
URI: http://hdl.handle.net/1942/24116
DOI: 10.1038/srep43410
ISI #: 000394754500001
ISSN: 2045-2322
Category: A1
Type: Journal Contribution
Validation: ecoom, 2018
Appears in Collections: Research publications

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