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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/24037

Title: High prevalence of epilepsy in onchocerciasis endemic regions in the Democratic Republic of the Congo
Authors: Levick, Bethany
Laudisoit, Anne
Tepage, Floribert
Ensoy-Musoro, Chellafe
Mandro, Michel
Osoro, Caroline Bonareri
Suykerbuyk, Patrick
Kashama, Jean-Marie
Komba, Michel
Tagoto, Alliance
Falay, Dadi
Begon, Michael
Colebunders, Robert
Issue Date: 2017
Citation: PLoS Neglected Tropical Diseases, 11(7), (Art N° e0005732)
Abstract: An increased prevalence of epilepsy has been reported in many onchocerciasis endemic areas. Between July 2014 and February 2016, house-to-house epilepsy prevalence surveys were carried out in the Bas-Uele, Tshopo and Ituri province of the Democratic Republic of the Congo, in areas with a high level of onchocerciasis endemicity. Of 12, 408 people examined in the different health areas 407 (3.3%) were found to have a history of epilepsy. A nested case control analysis demonstrated that before the appearance of epilepsy, compared to the same life period in controls, persons with epilepsy were around two times less likely to have taken Ivermectin than controls. Our data suggests that Ivermectin protects against epilepsy in an onchocerciasis endemic region. However, a prospective population based intervention study is needed to confirm this.
Notes: Colebunders, R (reprint author), Univ Antwerp, Global Hlth Inst, Antwerp, Belgium. robert.colebunders@uantwerpen.be
URI: http://hdl.handle.net/1942/24037
DOI: 10.1371/journal.pntd.0005732
ISI #: 000408057300044
ISSN: 1935-2735
Category: A1
Type: Journal Contribution
Appears in Collections: Research publications

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