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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/24026

Title: Forgotten antibiotics: a follow-up inventory study in Europe, the USA, Canada and Australia
Authors: Pulcini, Celine
Mohrs, Simone
Beovic, Bojana
Gyssens, Inge
Theuretzbacher, Ursula
Cars, Otto
Issue Date: 2017
Abstract: The objective of this study was to update a 2011 survey, conducted on behalf of the ESCMID Study Group for Antibiotic Policies (ESGAP), studying the availability of old but clinically useful antibiotics in North America, Europe and Australia. This follow-up survey was performed in 2015 in 40 countries among specialists from the pharmaceutical, infectious diseases and microbiology sectors in North America, Europe and Australia in order to assess the availability through usual marketing processes of 36 systemic antibiotics (addition of 3 antibiotics compared with the 2011 survey) selected for their ability to treat infections caused by resistant bacteria and their unique value for specific criteria. The questionnaire was sent by e-mail to national contacts belonging to ESGAP and ReAct networks. In all, 39 of the 40 countries participated in this survey. The number of available antibiotics differed considerably from one drug to another as well as from one country to another (e.g. 7 antibiotics available in Estonia, 24 in France). Overall, 25/36 selected antibiotics were marketed in 20/39 countries or less. From 2011 to 2015 (data available for both periods in 37 countries for 33 antibiotics), the number of available selected antibiotics increased in 13 countries and decreased in 17. In conclusion, despite the ongoing bacterial resistance crisis, the situation regarding the availability of 'forgotten antibiotics' has worsened since 2011. Urgent measures are needed to ensure better availability of these antibiotics on a global scale as a conservation measure to ensure sustainable and responsible use of antibiotics. (C) 2016 Elsevier B.V. and International Society of Chemotherapy. All rights reserved.
Notes: [Pulcini, Celine] Univ Lorraine, Ctr Hosp Reg Univ CHRU Nancy, Fac Med, Serv Malad Infect & Trop, Rue Morvan, F-54511 Nancy, France. [Mohrs, Simone; Cars, Otto] Uppsala Univ, Dept Med Sci, ReAct Act Antibiot Resistance, Uppsala, Sweden. [Beovic, Bojana] Univ Med Ctr Ljubljana, Ljubljana, Slovenia. [Gyssens, Inge] Radboud Univ Nijmegen, Med Ctr, Dept Med, Nijmegen, Netherlands. [Gyssens, Inge] Canisius Wilhelmina Hosp, Dept Med Microbiol & Infect Dis, Nijmegen, Netherlands. [Gyssens, Inge] Hasselt Univ, Hasselt, Belgium. [Theuretzbacher, Ursula] Ctr Antiinfect Agents, Vienna, Austria.
URI: http://hdl.handle.net/1942/24026
DOI: 10.1016/j.ijantimicag.2016.09.029
ISI #: 000396429300014
ISSN: 0924-8579
Category: A1
Type: Journal Contribution
Appears in Collections: Research publications

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