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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/23936

Title: Left Ventricular Structure and Function in Relation to Environmental Exposure to Lead and Cadmium
Authors: Yang, Wen-Yi
Zhang, Zhen-Yu
Thijs, Lutgarde
Cauwenberghs, Nicholas
Wei, Fang-Fei
Jacobs, Lotte
Luttun, Aernout
Verhamme, Peter
Kuznetsova, Tatiana
Nawrot, Tim S.
Staessen, Jan A.
Issue Date: 2017
Citation: JOURNAL OF THE AMERICAN HEART ASSOCIATION, 6(2), p. 1-12 (Art N° e004692)
Abstract: Background-Experimental studies have demonstrated that lead and cadmium have direct toxic effects on the myocardium, but the few human studies are limited by design, assessment of exposure, and use of heart failure as a late-stage endpoint. Methods and Results-In a prospective population study, we studied the association of left ventricular (LV) function with blood lead (BPb) and 24-hour urinary cadmium (UCd). In 179 participants randomly recruited from a Flemish population (50.3% women; mean age 39.1 years), geometric mean BPb and UCd at enrollment (1985-2000) were 0.20 mu mol/L and 6.1 nmol, respectively. We assessed systolic and diastolic LV function 11.9 years (median) later (2005-2010) by using Doppler imaging of the transmitral blood flow and the mitral annular movement and speckle tracking. In multivariable-adjusted linear regression, LV systolic function decreased with BPb. For a doubling of exposure, estimates were -0.392% for global longitudinal strain (P=0.034), -0.618% and -0.113 s (1) for regional longitudinal strain (P=0.028)and strain rate (P=0.008), and -0.056 s (1) for regional radial strain rate (P=0.050). Regional longitudinal strain rate (-0.066 s (1), P=0.009)and regional radial strain (-2.848%, P=0.015) also decreased with UCd. Models including both exposure indexes did not allow differentiating whether LV dysfunction was predominately related to BPb or UCd. Diastolic LV function was not associated with BPb or UCd (P=0.159). Conclusions-Although effect sizes were small, our results suggest that environmental exposure to lead, cadmium, or both might be a risk factor for systolic LV dysfunction, a condition often proceeding to heart failure.
Notes: [Yang, Wen-Yi; Zhang, Zhen-Yu; Thijs, Lutgarde; Cauwenberghs, Nicholas; Wei, Fang-Fei; Jacobs, Lotte; Kuznetsova, Tatiana; Staessen, Jan A.] Univ Leuven, KU Leuven Dept Cardiovasc Sci, Res Unit Hypertens & Cardiovasc Epidemiol, Studies Coordinating Ctr, Kapucijnenvoer 35, BE-3000 Leuven, Belgium. [Luttun, Aernout; Verhamme, Peter] Univ Leuven, KU Leuven Dept Cardiovasc Sci, Ctr Mol & Vasc Biol, BE-3000 Leuven, Belgium. [Nawrot, Tim S.] Univ Hasselt, Ctr Environm Sci, Hasselt, Belgium. [Staessen, Jan A.] Maastricht Univ, R&D Grp VitaK, Maastricht, Netherlands.
URI: http://hdl.handle.net/1942/23936
Link to publication: http://jaha.ahajournals.org/content/6/2/e004692
DOI: 10.1161/JAHA.116.004692
ISI #: 000393594700008
ISSN: 2047-9980
Category: A1
Type: Journal Contribution
Validation: ecoom, 2018
Appears in Collections: Research publications

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