Document Server@UHasselt >
Research >
Research publications >

Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/23908

Title: Postoperative radiotherapy in stage III non-small cell lung cancer: Is a reassessment necessary in modern times?
Authors: Billiet, Charlotte
Advisors: Mebis, Jeroen
De Ruysscher, Dirk
Issue Date: 2017
Abstract: Background: The role of postoperative radiation therapy (PORT) in patients with completely resected non-small cell lung cancer (NSCLC) with pathologically involved mediastinal lymph nodes (N2) remains unclear. Despite a reduction of local recurrence (LR), its effect on overall survival (OS) remains unproven. Therefore we conducted a review of the current literature. Methods: To investigate the benefit and safety of modern PORT, we identified published phase III trials for PORT. We investigated modern PORT in low-risk (ypN0/1 and R0) and high-risk (ypN2 and/or R1/2) patients with stage III-N2 NSCLC treated with induction chemotherapy and resection. Results: Seventeen phase III trials using PORT were selected. Of all PORT N2 studies, 4 were eligible for evaluation of LR, all in high-risk patients only. In these highrisk patients receiving PORT, the mean LR rate at 5 years was 20.9% (95% CI 16–24). Two trials were suitable to assess LR rates after chemotherapy and surgery without PORT. In these low-risk patients, the mean 5-year LR was 33.1% (95% CI 27–39). No significant difference in non-cancer deaths between PORT vs. non-PORT patients was observed in N2 NSCLC. Conclusion: PORT is worth the controversy because data illustrate that PORT may increase the OS. However, prospective randomized trials are needed to verify this.
URI: http://hdl.handle.net/1942/23908
Category: T1
Type: Theses and Dissertations
Appears in Collections: PhD theses
Research publications

Files in This Item:

Description SizeFormat
N/A3.11 MBAdobe PDF

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.