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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/2379

Title: Protein biomarkers for breast cancer prevention
Authors: JANSSENS, Jaak
VERLINDEN, Ilse
GUNGOR, Nejla
RAUS, Jef
MICHIELS, Luc
Issue Date: 2004
Publisher: LIPPINCOTT WILLIAMS & WILKINS
Citation: EUROPEAN JOURNAL OF CANCER PREVENTION, 13(4). p. 307-317
Abstract: Protein biomarkers suitable for the prevention of breast cancer must be extremely sensitive, easily detectable and highly correlated with the disease. They should be expressed in the reversible phase of carcinogenesis. Among the large number of candidate tumour-associated proteins, those related to the oestrogen/chorionic gonadotropin/insulin pathway seem to be of most interest because these can be causally implicated. They presumably are the first to express differently and are open to hormonal treatments. The biomarkers that give information on membrane receptor-modulated signal transduction should be considered as well. Up to now, only tamoxifen has shown some preventive activity, suggesting that the oestrogen pathway is useful indeed. Fenretinide and recombinant human chorionic gonatotropin (hCG) are also promising. But the financial requirements and the very long assessment periods largely prevent current research. This is precisely why we badly need to give priority to molecular biology research, in particular in the protein compartment. There is widespread belief that advanced proteomics together with increased informatics can provide specific combinations of disease-related expression profiles that could identify high-risk groups with much more reliability and allow us to monitor preventive strategies. (C) 2004 Lippincott Williams Wilkins.
Notes: Limburgs Univ Ctr, B-3590 Diepenbeek, Belgium.Janssens, JP, Limburgs Univ Ctr, Univ Campus, B-3590 Diepenbeek, Belgium.Janssens.ecp@skynet.be
URI: http://hdl.handle.net/1942/2379
Link to publication: http://www.eurjcancerprev.com/pt/re/ejcp/abstract.00008469-200408000-00011.htm;jsessionid=LkZRpXTv1lgwHgPHcQ4VbG2BmpLkm1RGGdG1rMwTFWLwgShrp6nh!-1696092046!181195628!8091!-1
ISI #: 000223481900011
ISSN: 0959-8278
Category: A1
Type: Journal Contribution
Validation: ecoom, 2005
Appears in Collections: Research publications

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