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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/23764

Title: The Effect of Maternal Pertussis Immunization on Infant Vaccine Responses to a Booster Pertussis-Containing Vaccine in Vietnam
Authors: Maertens, Kirsten
Thi Thu Ha Hoang
Trung Dac Nguyen
Cabore, Raissa Nadege
Thi Hong Duong
Huygen, Kris
Hens, Niel
Van Damme, Pierre
Duc Anh Dang
Leuridan, Elke
Issue Date: 2016
Abstract: Background. Maternal vaccination with an acellular pertussis (aP)-containing vaccine is a recommended strategy in a growing number of industrialized countries, to protect young infants from disease. Little is known on the effect of this strategy in low-and middle-income countries. Following a previous report on the effect of adding a pertussis and diphtheria component to the tetanus vaccination program in pregnant women in Vietnam, we report on infant immune responses to a booster aP vaccine dose in this randomized controlled clinical trial. Methods. Thirty infants of Tdap (tetanus, diphtheria, and acellular pertussis)-vaccinated pregnant women and 37 infants of women vaccinated with a tetanus-only vaccine received a fourth aP-containing vaccine dose in the second year of life. Blood was taken 1 month after the fourth infant dose. Immunoglobulin G (IgG) antibodies against pertussis toxin (PT), filamentous hemagglutinin (FHA), pertactin (Prn), tetanus toxoid (TT), and diphtheria toxoid (DT) were measured using commercially available enzyme-linked immunosorbent assays (ELISA). Results. One month after the booster dose, significantly lower antibody titers were measured in the Tdap group for anti-TT IgG (P < .001) only. Anti-DT IgG, anti-PT IgG, anti-Prn IgG, and anti-FHA IgG antibody titers were comparable for both groups. A rise in antibody concentrations was elicited for all (except DT) antigens after boosting. Conclusions. The present results indicate that the blunting of infant pertussis responses induced by maternal immunization, measured after a primary series of aP vaccines, was resolved with the booster aP vaccine dose. These results add to the evidence for national and international decision makers on maternal immunization as a vaccination strategy for protection of young infants against infectious diseases.
Notes: [Maertens, Kirsten; Van Damme, Pierre; Leuridan, Elke] Univ Antwerp, Vaccine & Infect Dis Inst, Ctr Evaluat Vaccinat, Univ Pl 1, B-2610 Antwerp, Belgium. [Thi Thu Ha Hoang; Trung Dac Nguyen; Thi Hong Duong; Duc Anh Dang] Natl Inst Hyg & Epidemiol, Dept Bacteriol, Hanoi, Vietnam. [Cabore, Raissa Nadege; Huygen, Kris] Sci Inst Publ Hlth, Natl Reference Ctr Bordetella, Natl Reference Ctr Toxigen Corynebacteria, Serv Immunol, Brussels, Belgium. [Hens, Niel] Hasselt Univ, Interuniv Inst Biostat & Stat Bioinformat, Hasselt, Belgium. [Hens, Niel] Univ Antwerp, Vaccine & Infect Dis Inst, Ctr Hlth Econ Res & Modeling Infect Dis, Antwerp, Belgium.
URI: http://hdl.handle.net/1942/23764
DOI: 10.1093/cid/ciw551
ISI #: 000392714700012
ISSN: 1058-4838
Category: A1
Type: Journal Contribution
Appears in Collections: Research publications

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