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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/23723

Title: Methylglyoxal-derived advanced glycation endproducts in multiple sclerosis
Authors: Wetzels, Suzan
Wouters, Kristiaan
Schalkwijk, Casper G.
Vanmierlo, Tim
Hendriks, Jerome J. A.
Issue Date: 2017
Publisher: MDPI AG
Abstract: Multiple sclerosis (MS) is a demyelinating disease of the central nervous system (CNS). The activation of inflammatory cells is crucial for the development of MS and is shown to induce intracellular glycolytic metabolism in pro-inflammatory microglia and macrophages, as well as CNS-resident astrocytes. Advanced glycation endproducts (AGEs) are stable endproducts formed by a reaction of the dicarbonyl compounds methylglyoxal (MGO) and glyoxal (GO) with amino acids in proteins, during glycolysis. This suggests that, in MS, MGO-derived AGEs are formed in glycolysis-driven cells. MGO and MGO-derived AGEs can further activate inflammatory cells by binding to the receptor for advanced glycation endproducts (RAGE). Recent studies have revealed that AGEs are increased in the plasma and brain of MS patients. Therefore, AGEs might contribute to the inflammatory status in MS. Moreover, the main detoxification system of dicarbonyl compounds, the glyoxalase system, seems to be affected in MS patients, which may contribute to high MGO-derived AGE levels. Altogether, evidence is emerging for a contributing role of AGEs in the pathology of MS. In this review, we provide an overview of the current knowledge on the involvement of AGEs in MS.
Notes: [Wetzels, Suzan; Wouters, Kristiaan; Schalkwijk, Casper G.] Maastricht Univ, Cardiovasc Res Inst Maastricht, Dept Internal Med, NL-6229 Maastricht, Netherlands. [Wetzels, Suzan; Vanmierlo, Tim; Hendriks, Jerome J. A.] Hasselt Univ, Biomed Res Inst, Dept Immunol & Biochem, Martelarenlaan 42, B-3500 Hasselt, Belgium.
URI: http://hdl.handle.net/1942/23723
DOI: 10.3390/ijms18020421
ISI #: 000395457700189
ISSN: 1422-0067
Category: A1
Type: Journal Contribution
Appears in Collections: Research publications

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