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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/23722

Title: CD169 is a marker for highly pathogenic phagocytes in multiple sclerosis
Authors: Bogie, Jeroen F. J.
Boelen, Ellen
Louagie, Els
Delputte, Peter
Elewaut, Dirk
Van Horssen, Jack
Hendriks, Jerome J. A.
Hellings, Niels
Issue Date: 2018
Citation: Multiple Sclerosis Journal, 24(3), p. 290-300
Abstract: Background: Phagocytes, such as macrophages and microglia, are key effector cells in the pathophysiology of multiple sclerosis (MS). It is widely accepted that they instigate and promote neuroinflammatory and neurodegenerative events in MS. An increasing amount of studies indicate that Siglec-1, also known CD169, is a marker for activated phagocytes in inflammatory disorders. Objective: In this study, we set out to define how CD169+ phagocytes contribute to neuroinflammation in MS. Methods: CD169-diphteria toxin receptor (DTR) mice, which express human DTR under control of the CD169 promoter, were used to define the impact of CD169+ cells on neuroinflammation. Flow cytometry and immunohistochemistry were utilized to determine the expression and distribution of CD169. Results: We show that CD169 is highly expressed by lesional and circulating phagocytes in MS and experimental autoimmune encephalomyelitis (EAE). Our data further indicate that CD169 represents a selective marker for early activated microglia in MS and EAE lesions. Depletion of CD169+ cells markedly reduced neuroinflammation and ameliorated disease symptoms in EAE-affected mice. Conclusion: Our findings indicate that CD169+ cells promote neuroinflammation. Furthermore, they suggest that CD169+ phagocytes play a key role in the pathophysiology of MS. Hence, targeting CD169+ phagocytes cells may hold therapeutic value for MS.
URI: http://hdl.handle.net/1942/23722
DOI: 10.1177/1352458517698759
ISSN: 1352-4585
Category: A1
Type: Journal Contribution
Appears in Collections: Research publications

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