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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/23717

Title: Scavenger receptor collectin placenta 1 is a novel receptor 1 involved in the uptake of myelin by phagocytes
Authors: Bogie, Jeroen F. J.
Mailleux, Jo
Wouters, Elien
Jorissen, Winde
Grajchen, Elien
Vanmol, Jasmine
Wouters, Kristiaan
Hellings, Niels
Van Horsen, Jack
Vanmierlo, Tim
Hendriks, Jerome
Issue Date: 2017
Citation: Scientific Reports, 7, p. 1-9 (Art N° 44794)
Abstract: Myelin-containing macrophages and microglia are the most abundant immune cells in active multiple sclerosis (MS) lesions. Our recent transcriptomic analysis demonstrated that collectin placenta 1 (CL-P1) is one of the most potently induced genes in macrophages after uptake of myelin. CL-P1 is a type II transmembrane protein with both a collagen-like and carbohydrate recognition domain, which plays a key role in host defense. In this study we sought to determine the dynamics of CL-P1 expression on myelin-containing phagocytes and define the role that it plays in MS lesion development. We show that myelin uptake increases the cell surface expression of CL-P1 by mouse and human macrophages, but not by primary mouse microglia in vitro. In active demyelinating MS lesions, CL-P1 immunoreactivity was localized to perivascular and parenchymal myelin-laden phagocytes. Finally, we demonstrate that CL-P1 is involved in myelin internalization as knockdown of CL-P1 markedly reduced myelin uptake. Collectively, our data indicate that CL-P1 is a novel receptor involved in myelin uptake by phagocytes and likely plays a role in MS lesion development.
Notes: Hendriks, JJA (reprint author) , Hasselt Univ, Transnat Univ Limburg, Sch Life Sci, Inst Biomed Res, Diepenbeek, Belgium. Jerome.hendriks@uhasselt.be
URI: http://hdl.handle.net/1942/23717
DOI: 10.1038/srep44794
ISI #: 000397177700001
ISSN: 2045-2322
Category: A1
Type: Journal Contribution
Appears in Collections: Research publications

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