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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/23715

Title: The effect of active fluctuations on the dynamics of particles, motors and DNA-hairpins
Authors: Vandebroek, Hans
Vanderzande, Carlo
Issue Date: 2017
Citation: Soft Matter, 13(11), p. 2181-2191
Abstract: Inspired by recent experiments on the dynamics of particles and polymers in artificial cytoskeletons and in cells, we introduce a modified Langevin equation for a particle in an environment that is a viscoelastic medium and that is brought out of equilibrium by the action of active fluctuations caused by molecular motors. We show that within such a model, the motion of a free particle crosses over from superdiffusive to subdiffusive as observed for tracer particles in an in vitro cytoskeleton or in a cell. We investigate the dynamics of a particle confined by a harmonic potential as a simple model for the motion of the tethered head of kinesin-1. We find that the probability that the head is close to its binding site on the microtubule can be enhanced by a factor of two due to active forces. Finally, we study the dynamics of a particle in a double well potential as a model for the dynamics of DNA-hairpins. We show that the active forces effectively lower the potential barrier between the two minima and study the impact of this phenomenon on the zipping/unzipping rate.
Notes: Vanderzande, C (reprint author), Hasselt Univ, Fac Sci, B-3590 Diepenbeek, Belgium. hans.vandebroek@uhasselt.be; carlo.vanderzande@uhasselt.be
URI: http://hdl.handle.net/1942/23715
DOI: 10.1039/c6sm02568d
ISI #: 000397955800006
ISSN: 1744-683X
Category: A1
Type: Journal Contribution
Appears in Collections: Research publications

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