Document Server@UHasselt >
Research publications >
Please use this identifier to cite or link to this item:
|Title: ||The effect of active fluctuations on the dynamics of particles, motors and DNA-hairpins|
|Authors: ||Vandebroek, Hans|
|Issue Date: ||2017|
|Citation: ||Soft Matter, 13(11), p. 2181-2191|
|Abstract: ||Inspired by recent experiments on the dynamics of particles and polymers in artificial cytoskeletons and in cells, we introduce a modified Langevin equation for a particle in an environment that is a viscoelastic medium and that is brought out of equilibrium by the action of active fluctuations caused by molecular motors. We show that within such a model, the motion of a free particle crosses over from superdiffusive to subdiffusive as observed for tracer particles in an in vitro cytoskeleton or in a cell. We investigate the dynamics of a particle confined by a harmonic potential as a simple model for the motion of the tethered head of kinesin-1. We find that the probability that the head is close to its binding site on the microtubule can be enhanced by a factor of two due to active forces. Finally, we study the dynamics of a particle in a double well potential as a model for the dynamics of DNA-hairpins. We show that the active forces effectively lower the potential barrier between the two minima and study the impact of this phenomenon on the zipping/unzipping rate.|
|Notes: ||Vanderzande, C (reprint author), Hasselt Univ, Fac Sci, B-3590 Diepenbeek, Belgium.
|ISI #: ||000397955800006|
|Type: ||Journal Contribution|
|Appears in Collections: ||Research publications|
Files in This Item:
|Published version||3.09 MB||Adobe PDF|
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.