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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/2371

Title: Efficacy and safety of four doses of lumiracoxib versus diclofenac in patients with knee or hip primary osteoarthritis: A phase II, four-week, multicenter, randomized, double-blind, placebo-controlled trial
Authors: Schnitzer, TJ
Beier, J.
Hasler, P
Patel, SK
Senftleber, I
Gitton, X
Moore, A.
Sloan, VS
Poor, G
Issue Date: 2004
Publisher: WILEY-LISS
Abstract: Objective. To compare the efficacy and tolerability of the novel cyclooxygenase 2-selective inhibitor lumiracoxib with placebo and diclofenac in osteoarthritis (OA). Methods. Adults (n = 583) with knee or hip OA were randomized to receive for 4 weeks lumiracoxib 50, 100, or 200 mg twice daily or 400 mg once daily; placebo; or diclofenac 75 mg twice daily. Efficacy assessments included overall joint pain intensity and Western Ontario and McMaster Universities Osteoarthritis Index subscales; tolerability was evaluated by adverse event and physician reporting. Results. All lumiracoxib doses were superior to placebo in relieving pain, improving stiffness, and improving physical function after 4 weeks. At study endpoint, pain relief was comparable among all lumiracoxib dosages and similar to diclofenac. Lumiracoxib tolerability was superior to diclofenac and comparable to placebo. Conclusion. Lumiracoxib provides predictable and sustained relief from pain, stiffness, and impaired physical function in OA. Lumiracoxib shows clinically comparable efficacy and superior tolerability to diclofenac.
Notes: Northwestern Univ, Feinberg Sch Med, Chicago, IL 60611 USA. Univ Limburg, Diepenbeek, Belgium. Felix Platter Hosp, Basel, Switzerland. Adan House Surg, Durham, England. Novartis Pharma AG, Basel, Switzerland. Novartis Pharmaceut Corp, E Hanover, NJ USA. Natl Inst Rheumatism & Physiotherapy, Budapest, Hungary.Schnitzer, TJ, Northwestern Ctr Clin Res, 710 N Lake Shore Dr,Room 1020, Chicago, IL 60611 USA.tjs@northwestern.edu
URI: http://hdl.handle.net/1942/2371
DOI: 10.1002/art.20525
ISI #: 000223183100007
ISSN: 0004-3591
Category: A1
Type: Journal Contribution
Validation: ecoom, 2005
Appears in Collections: Research publications

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