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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/23641

Title: Importance of Abnormal Chloride Homeostasis in Stable Chronic Heart Failure
Authors: Grodin, Justin L.
Verbrugge, Frederik H.
Ellis, Stephen G.
Mullens, Wilfried
Testani, Jeffrey M.
Tang, W. H. Wilson
Issue Date: 2016
Citation: CIRCULATION-HEART FAILURE, 9(1) (Art N° e002453)
Abstract: Background—The aim of this analysis was to determine the long-term prognostic value of lower serum chloride in patients with stable chronic heart failure. Electrolyte abnormalities are prevalent in patients with chronic heart failure. Little is known regarding the prognostic implications of lower serum chloride. Methods and Results—Serum chloride was measured in 1673 consecutively consented stable patients with a history of heart failure undergoing elective diagnostic coronary angiography. All patients were followed for 5-year all-cause mortality, and survival models were adjusted for variables that confounded the chloride–risk relationship. The average chloride level was 102±4 mEq/L. Over 6772 person-years of follow-up, there were 547 deaths. Lower chloride (per standard deviation decrease) was associated with a higher adjusted risk of mortality (hazard ratio 1.29, 95% confidence interval 1.12–1.49; P
URI: http://hdl.handle.net/1942/23641
DOI: 10.1161/CIRCHEARTFAILURE.115.002453
ISI #: 000368620100001
ISSN: 1941-3289
Category: A1
Type: Journal Contribution
Validation: ecoom, 2017
Appears in Collections: Research publications

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