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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/23627

Title: Plasma Volume Is Normal but Heterogeneously Distributed, and True Anemia Is Highly Prevalent in Patients With Stable Heart Failure
Authors: Nijst, Petra
Verbrugge, Frederik H.
Bertrand, Philippe B.
Martens, Pieter
Dupont, Matthias
Drieskens, Olivier
Penders, Joris
Tang, W. H. Wilson
Mullens, Wilfried
Issue Date: 2017
Citation: JOURNAL OF CARDIAC FAILURE, 23(2), p. 138-144
Abstract: Background: Intravascular volume overload and depletion as well as anemia are associated with increased hospital admissions and mortality in patients with heart failure. This study aimed to accurately measure plasma volume and red cell mass (RCM) in stable patients with chronic heart failure with reduced ejection fraction (HFrEF) and gain more insight into plasma volume regulation and anemia in stable conditions of HFrEF. Methods and Results: Plasma volume and RCM measurement based on 99Tc-labeled red blood cells, venous blood sample,s and clinical parameters were obtained in 24 stable HFrEF patients under optimal medical therapy. Measured plasma volume values were compared with predicted values based on body surface area. Plasma volume was on average normal (99.98% of predicted) but heterogeneously distributed (variations of 81%–133%). Neurohumoral activation and medication use were not associated with plasma volume status. Furthermore, anemia based on actual measurement of RCM was present in up to 75% of subjects, but rarely hemodilutional. Conclusions: In stable chronic HFrEF patients under optimal medical therapy, plasma volume is overall normal but heterogeneously distributed. Anticipated factors such as neurohumoral activation and heart failure medication were not associated with plasma volume. Furthermore, anemia is more common than as assessed by hemoglobin. (J Cardiac Fail 2017;23:138–144)
Notes: [Nijst, Petra; Verbrugge, Frederik H.; Bertrand, Philippe B.; Martens, Pieter; Dupont, Matthias; Mullens, Wilfried] Ziekenhuis Oost Limburg, Dept Cardiol, Schiepse Bos 6, B-3600 Genk, Belgium. [Nijst, Petra; Bertrand, Philippe B.] Hasselt Univ, Doctoral Sch Med & Life Sci, Diepenbeek, Belgium. [Penders, Joris; Mullens, Wilfried] Hasselt Univ, Fac Med & Life Sci, Biomed Res Inst, Diepenbeek, Belgium. [Drieskens, Olivier] Ziekenhuis Oost Limburg, Dept Nucl Med, Genk, Belgium. [Tang, W. H. Wilson] Cleveland Clin, Inst Heart & Vasc, Dept Cardiovasc Med, Cleveland, OH 44106 USA.
URI: http://hdl.handle.net/1942/23627
DOI: 10.1016/j.cardfail.2016.08.008
ISI #: 000393535300008
ISSN: 1071-9164
Category: A1
Type: Journal Contribution
Validation: ecoom, 2018
Appears in Collections: Research publications

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