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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/2362

Title: Clinical vertebral fractures in patients with ankylosing spondylitis
Authors: Vosse, D
Feldtkeller, E
Erlendsson, J
van der Linden, S
Issue Date: 2004
Citation: JOURNAL OF RHEUMATOLOGY, 31(10). p. 1981-1985
Abstract: Objective. To evaluate the prevalence and characteristics of clinically confirmed vertebral fractures (CVF) in patients with ankylosing spondylitis (AS). Methods. Coordinated by the Ankylosing Spondylitis International Federation in Germany and in Denmark, a self-administered questionnaire was sent to all their members about age, diagnosis, disease duration, HLA-B27 status, and history of CVF. Patients who were aware of having had a CVF were asked to return the questionnaire with additional specification of the location of CVF, associated trauma, neurological complications, therapy for these complications, and recovery. We also reviewed available radiographs. Results. Out of 15,097 questionnaires, 59 patients (0.4%) reporting 66 CVF returned the complete questionnaire (46 men, 13 women). Mean age at fracture was 50 9 years, after a mean duration of symptoms of 26 It years. CVF with wedging or crush or transverse fracture were reported in the cervical (n = 21, 36%), thoracic (n = 21, 36%), and lumbar spine (n = 16, 27%), with one unspecified. In 37 fractures (56%), patients reported no/low or medium trauma in relation to the fracture. In 31 fractures (47%), patients reported neurological complications, occurring mostly without trauma (n = 11, 35%) or after minimal trauma (n = 7, 23%). Twenty (65%) of these patients did not have full neurological recovery. Conclusion. We found that 0.4% of patients with AS reported CVF at a mean age of 50 years, occurring after 2 decades of disease, mainly without trauma or after minimal trauma, with frequent neurological complications mostly followed by incomplete neurological recovery.
Notes: Univ Hosp Maastricht, Dept Internal Med, Div Rheumatol, NL-6202 AZ Maastricht, Netherlands. Limburgs Univ Ctr, Dept Rheumatol, Diepenbeek, Belgium. Dept Internal Med, Div Rheumatol, Horsens Sygenhus, Horsens, Denmark.Vosse, D, Univ Hosp Maastricht, Dept Internal Med, Div Rheumatol, POB 5800, NL-6202 AZ Maastricht, Netherlands.dvo@sint.azm.nl
URI: http://hdl.handle.net/1942/2362
Link to publication: http://jrheum.com/abstracts/abstracts04/1981.html
ISI #: 000224326900019
ISSN: 0315-162X
Category: A1
Type: Journal Contribution
Validation: ecoom, 2005
Appears in Collections: Research publications

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