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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/2361

Title: Influence of breathing pattern and lung inflation on impulse oscillometry measurements in horses
Authors: Van Erck, E
Votion, D
Kirschvink, N
Genicot, B
Art, T.
Lekeux, P
Issue Date: 2004
Citation: VETERINARY JOURNAL, 168(3). p. 259-269
Abstract: The objective of this paper was to determine if changes in ventilation patterns could influence the outcome of respiratory function measurements performed with our impulse oscillometry system (IOS) in horses. In a first study, IOS tests were performed in vitro on six isolated equine lungs. Lung inflation levels were controlled by modifying depressurisation inside an artificial thorax and different ventilation patterns were imposed. In a second in vivo study, transient variations in breathing pattern were evaluated both with the IOS and a current reference technique (CRT) in five healthy mature horses after an intravenous (i.v.) injection of lobefine hydrochloride. In both studies, respiratory rate (RR, range: 7-42 breaths/min.) and tidal volume (V-T, range: 0.4-25 L) had minor or no influence on IOS parameters. The influence of lung inflation, most marked for resistance at 5 Hz (R-5 (Hz)), was limited for the considered physiological range. In vivo, statistical models indicated that maximal changes in pleural pressure (MaxDeltaPpl) and peak flows were the main determinants of the variability of the resistance (R-rs) and the reactance (X-rs) of the respiratory system. The fourfold increase in baseline MaxDeltaPpl and peak flows obtained during hyperpnoea caused a significant increase in R-rs at 5 and 10 Hz and a decrease in X,, at all frequencies. We conclude that IOS parameters are not influenced by tachypnoea, but will reflect alterations in respiratory mechanics caused by hyperpnoeic breathing. (C) 2003 Elsevier Ltd. All rights reserved.
Notes: Univ Liege, Lab Funct Invest, Dept Physiol, Fac Med Vet, B-4000 Liege, Belgium. Limburgs Univ Centrum, Dept Biostat, Diepenbeek, Belgium.Van Erck, E, Univ Liege, Lab Funct Invest, Dept Physiol, Fac Med Vet, Bat B42, B-4000 Liege, Belgium.emmanuelle.vanerck@skynet.be
URI: http://hdl.handle.net/1942/2361
DOI: 10.1016/j.tvjl.2003.09.010
ISI #: 000225110200010
ISSN: 1090-0233
Category: A1
Type: Journal Contribution
Validation: ecoom, 2005
Appears in Collections: Research publications

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