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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/23380

Title: The Assessment of Motor Fatigability in Persons With Multiple Sclerosis
Authors: Severijns, Deborah
Zijdewind, Inge
Dalgas, Ulrik
Lamers, Ilse
Lismont, Caroline
Feys, Peter
Issue Date: 2017
Citation: Neurorehabilitation and neural repair,
Abstract: Background. Persons with multiple sclerosis (PwMS) are often characterized by increased motor fatigability, which is a performance change on an objectively measured criterion after any type of voluntary muscle contractions. This review summarizes the existing literature to determine which protocols and outcome measures are best to detect or study motor fatigability and the underlying mechanisms in MS. Methods. Two electronic databases, PubMed and Web of Science, were searched for relevant articles published until August 2016 with a combination of multiple sclerosis, fatigability, muscle fatigue, and motor fatigue. Results. A total of 48 articles were retained for data extraction. A variety of fatigability protocols were reported; protocols showed differences in type (isometric vs concentric), duration (15 to 180 s), and number of contractions (fixed or until exhaustion). Also, 12 articles reported motor fatigability during functional movements, predominantly assessed by changes in walking speed; 11 studies evaluated the mechanisms underlying motor fatigability, using additional electrical nerve or transcranial magnetic stimulation. Three articles reported psychometrics of the outcomes. Conclusions. The disparity of protocols and outcome measures to study different aspects of motor fatigability in PwMS impedes direct comparison between data. Most protocols use maximal single-joint isometric contractions, with the advantage of high standardization. Because there is no head-to-head comparison of the different protocols and only limited information on psychometric properties of outcomes, there is currently no gold standard to assess motor fatigability. The disability level, disease phenotype, and studied limb may influence the assessment of motor fatigability in PwMS.
Notes: [Severijns, Deborah; Lamers, Ilse; Lismont, Caroline; Feys, Peter] Hasselt Univ, Biomed Res Inst, Fac Med & Life Sci, REVAL Rehabil Res Res Ctr BIOMED, Bldg A, B-3590 Diepenbeek, Hasselt, Belgium. [Zijdewind, Inge] Univ Groningen, Univ Med Ctr Groningen, Dept Neurosci, Groningen, Netherlands. [Dalgas, Ulrik] Aarhus Univ, Sect Sport Sci, Dept Publ Hlth, Aarhus, Denmark.
URI: http://hdl.handle.net/1942/23380
DOI: 10.1177/1545968317690831
ISI #: 000399711600003
ISSN: 1545-9683
Category: A1
Type: Journal Contribution
Appears in Collections: Research publications

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