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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/23329

Title: Fabrication of precisely aligned microwire and microchannel structures: Toward heat stimulation of guided neurites in neuronal cultures
Authors: Dang, Ka My
Rinklin, Philipp
Schnitker, Jan
Haberkorn, Bastian
Zobel, Kathrin
Carolus, Jorne
Daenen, Michaël
Gribaudo, Simona
Perrier, Anselme L
Weigel, Stefan
Luksch, Harald
Offenhäusser, Andreas
Wolfrum, Bernhard
Issue Date: 2017
Status: In Press
Abstract: Microwire arrays are a powerful tool for the exertion of localized thermal stress on cellular networks. Combining microwire arrays with a set of orthogonal axon-guiding microchannels on-chip allows positioning of neurites as well as control over their polarity. In this paper, we present a new fabrication approach, based on standard clean roomfabrication and sacrificial layer etching for the integration ofmicrowire arrays into neurite guiding structures.The system permits the application of strong temperature gradients enabling localized thermal stimulation inside microchannels.
Notes: Wolfrum, B (reprint author), Tech Univ Munich, Dept Elect & Comp Engn, MSB, Neuroelect, Boltzmannstr 11, D-85748 Garching, Germany bernhard.wolfrum@tum.de
URI: http://hdl.handle.net/1942/23329
DOI: 10.1002/pssa.201600729
ISI #: 000409906900004
ISSN: 1862-6300
Category: A1
Type: Journal Contribution
Appears in Collections: Research publications

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