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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/23308

Title: Inflammation at the blood-brain barrier: The role of liver X receptors
Authors: de Wit, Nienke
Vanmol, Jasmine
Kamermans, A.
Hendriks, Jerome
de Vries, Elga
Issue Date: 2016
Citation: Neurobiology of disease, 107, pag. 57-65
Status: In Press
Abstract: The blood-brain barrier (BBB) is indispensable for the maintenance of brain homeostasis and proper neuronal functioning. Dysfunction of the BBB significantly contributes to the pathogenesis of neuroinflammatory and neurodegenerative diseases like stroke, multiple sclerosis (MS), and Alzheimer's disease (AD). The neuroinflammatory environment that characterizes these disorders propagates chronic impaired function of the BBB, processes that will be discussed in this review. Limiting dysfunction of the BBB may be an attractive target for treatment of neurological disorders. To date, no current treatments are directly targeting the function of the BBB. In this review, we will specifically discuss the potential protective role of nuclear liver X receptors (LXRs) as a promising therapeutic target to reverse or prevent BBB impairment in neurological diseases.
Notes: de Wit, NM (reprint author), Vrije Univ Amsterdam Med Ctr, Dept Mol Cell Biol & Immunol, Neurosci Campus Amsterdam, POB 7057, NL-1007 MB Amsterdam, Netherlands. n.dewit1@vumc.nl
URI: http://hdl.handle.net/1942/23308
DOI: 10.1016/j.nbd.2016.09.015
ISI #: 000411169900006
ISSN: 0969-9961
Category: A1
Type: Journal Contribution
Appears in Collections: Research publications

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