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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/23276

Title: Peripheral Artery Disease and Its Clinical Relevance in Patients with Chronic Obstructive Pulmonary Disease in the COPD and Systemic Consequences-Comorbidities Network Study
Authors: Houben-Wilkes, Sarah
Joerres, Rudolf A.
Bals, Robert
Franssen, Frits M. E.
Glaeser, Sven
Holle, Rolf
Karch, Annika
Koch, Armin
Magnussen, Helgo
Obst, Anne
Schulz, Holger
Spruit, Martijn A.
Wacker, Margarethe E.
Welte, Tobias
Wouters, Emiel F. M.
Vogelmeier, Claus
Watz, Henrik
Issue Date: 2017
Abstract: Rationale: Knowledge about the prevalence of objectively assessed peripheral artery disease (PAD) and its clinical relevance in patients with chronic obstructive pulmonary disease (COPD) is scarce. Objectives: We aimed to: (1) assess the prevalence of PAD in COPD compared with distinct control groups; and (2) study the association between PAD and functional capacity as well as health status. Methods: The ankle-brachial index was used to diagnose PAD (ankle-brachial index <= 0.9). The 6-minute-walk distance, health status (St. George's Respiratory Questionnaire), COPD Assessment Test, and EuroQol-5-Dimensions were assessed in patients enrolled in the German COPD and Systemic Consequences-Comorbidities Network cohort study. Control groups were derived from the Study of Health in Pomerania. Measurements and Main Results: A total of 2,088 patients with COPD (61.1% male; mean [SD] age, 65.3 [8.2] years, GOLD (Global Initiative for Chronic Obstructive Lung Disease) stages I-IV: 9.4, 42.5, 37.5, and 10.5%, respectively) were included, of which 184 patients (8.8%; GOLD stage I-IV: 5.1, 7.4, 11.1, and 9.5%, respectively, vs. 5.9% in patients with GOLD stage 0 in the COPD and Systemic Consequences-Comorbidities Network) had PAD. In the Study of Health in Pomerania, PAD ranged from 1.8 to 4.2%. Patients with COPD with PAD had a significantly shorter 6-minute-walk distance (356 [108] vs. 422 [103] m, P < 0.001) and worse health status (St. George's Respiratory Questionnaire: 49.7 [20.1] vs. 42.7 [20.0] points, P < 0.001; COPD Assessment Test: 19.6 [7.4] vs. 17.9 [7.4] points, P = 0.004; EuroQol-5-Dimensions visual analog scale: 51.2 [19.0] vs. 57.2 [19.6], P < 0.001). Differences remained significant after correction for several confounders. Conclusions: In a large cohort of patients with COPD, 8.8% were diagnosed with PAD, which is higher than the prevalence in control subjects without COPD. PAD was associated with a clinically relevant reduction in functional capacity and health status.
Notes: [Houben-Wilkes, Sarah; Franssen, Frits M. E.; Spruit, Martijn A.] CIRO, Dept Res & Educ, Hornerheide 1, NL-6085 NM Horn, Netherlands. [Joerres, Rudolf A.] Ludwig Maximilians Univ Munchen, Inst Outpatient Clin Occupat Social & Environm Me, Munich, Germany. [Bals, Robert] Saarland Univ Hosp, Dept Internal Med Pulmonol Allergol Resp Intens C, Homburg, Germany. [Franssen, Frits M. E.; Wouters, Emiel F. M.] Maastricht Univ, Med Ctr, Dept Resp Med, Maastricht, Netherlands. [Glaeser, Sven] Univ Med Greifswald, Dept Internal Med Cardiol Intens Care Pulm Med &, Greifswald, Germany. [Holle, Rolf] German Res Ctr Environm Hlth, Comprehens Pneumol Ctr Munich, German Ctr Lung Res,Helmholtz Zentrum Munchen Gmb, Inst Hlth Econ & Hlth Care Management, Neuherberg, Germany. [Schulz, Holger] German Res Ctr Environm Hlth, Comprehens Pneumol Ctr Munich, German Ctr Lung Res,Helmholtz Zentrum Munchen Gmb, Inst Epidemiol 1, Neuherberg, Germany. [Karch, Annika; Koch, Armin] Hannover Med Sch, German Ctr Lung Res, Inst Biostat, Hannover, Germany. [Welte, Tobias] Hannover Med Sch, German Ctr Lung Res, Clin Pneumol, Hannover, Germany. [Magnussen, Helgo] German Ctr Lung Res, Airway Res Ctr North, Lung Clin Grosshansdorf, Pulm Res Inst, Grosshansdorf, Germany. [Spruit, Martijn A.] Hasselt Univ, Fac Med & Life Sci, Biomed Res Inst, Rehabil Res Ctr, Diepenbeek, Belgium. [Vogelmeier, Claus] Philipps Univ, German Ctr Lung Res, Univ Med Ctr Giessen & Marburg, Dept Med Pulm & Crit Care Med, Marburg, Germany.
URI: http://hdl.handle.net/1942/23276
DOI: 10.1164/rccm.201602-0354OC
ISI #: 000391907300011
ISSN: 1073-449X
Category: A1
Type: Journal Contribution
Appears in Collections: Research publications

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