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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/23275

Title: Long-Term Motor Deficits after Controlled Cortical Impact in Rats Can Be Detected by Fine Motor Skill Tests but Not by Automated Gait Analysis
Authors: Schonfeld, Lisa-Maria
Jahanshahi, Ali
Lemmens, Evi
Schipper, Sandra
Dooley, Dearbhaile
Joosten, Elbert
Temel, Yasin
Hendrix, Sven
Issue Date: 2017
Citation: JOURNAL OF NEUROTRAUMA, 34(2), p. 505-516
Abstract: Animal models with constant, long-lasting motor deficits together with the right tests to assess behavioral abnormalities are needed to study the effectiveness of potential therapies to restore motor functions. In the current study, controlled cortical impact (CCI) was applied in rats to induce damage to the forelimb area of the motor cortex and the dorsal striatum. Motor behavior was assessed before and after CCI, using fine motor skill tests such as the adhesive removal test, the cylinder test, and the Montoya staircase test as well as the automated gait analysis system CatWalk XT over a 6 week period. CCI caused a variety of unilateral motor deficits, which were characterized in detail by using the selected fine motor skill tests. In striking contrast to previous studies on CCI in mice, neither forelimb impairments, nor general changes in gait, were detected with the CatWalk XT. These data suggest that the adhesive removal test, the cylinder test, and the Montoya staircase test are the methods of choice to detect long-term unilateral motor deficits in rats after CCI, whereas the use of automated gait analysis systems might not be suitable to measure these behavioral deviations.
Notes: [Schonfeld, Lisa-Maria; Lemmens, Evi; Dooley, Dearbhaile; Hendrix, Sven] Hasselt Univ, Biomed Res Inst BIOMED, Dept Morphol, Hasselt, Belgium. [Schonfeld, Lisa-Maria; Jahanshahi, Ali; Schipper, Sandra; Temel, Yasin] Maastricht Univ, Dept Neurosci, Maastricht, Netherlands. [Schipper, Sandra] Maastricht Univ, Med Ctr, Dept Neurol, Maastricht, Netherlands. [Dooley, Dearbhaile] Maastricht Univ, Med Ctr, Dept Anesthesiol & Pain Management, Maastricht, Netherlands. [Jahanshahi, Ali; Temel, Yasin] Maastricht Univ, Med Ctr, Dept Neurosurg, Maastricht, Netherlands.
URI: http://hdl.handle.net/1942/23275
DOI: 10.1089/neu.2016.4440
ISI #: 000391754800026
ISSN: 0897-7151
Category: A1
Type: Journal Contribution
Appears in Collections: Research publications

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