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|Title: ||The influence of single nucleotide polymorphisms on the association between dietary acrylamide intake and endometrial cancer risk|
|Authors: ||Hogervorst, Janneke|
van den Brandt, Piet A.
Godschalk, Roger W. L.
van Schooten, Frederik-Jan
Schouten, Leo J.
|Issue Date: ||2016|
|Publisher: ||NATURE PUBLISHING GROUP|
|Citation: ||SCIENTIFIC REPORTS, 6 (Art N° 34902)|
|Abstract: ||It is unclear whether the association between dietary acrylamide intake and endometrial cancer risk as observed in some epidemiological studies reflects a causal relationship. We aimed at clarifying the causality by analyzing acrylamide-gene interactions for endometrial cancer risk. The prospective Netherlands Cohort Study on diet and cancer includes 62,573 women, aged 55-69 years. At baseline, a random subcohort of 2589 women was selected for a case cohort analysis approach. Acrylamide intake of subcohort members and endometrial cancer cases (n = 315) was assessed with a food frequency questionnaire. Single nucleotide polymorphisms (SNPs) in genes in acrylamide metabolism, sex steroid systems, oxidative stress and DNA repair were assessed through a MassARRAY iPLEX Platform. Interaction between acrylamide and SNPs was assessed with Cox proportional hazards analysis, based on 11.3 years of follow-up. Among the results for 57 SNPs and 2 gene deletions, there were no statistically significant interactions after adjustment for multiple testing. However, there were nominally statistically significant interactions for SNPs in acrylamide-metabolizing enzymes: CYP2E1 (rs915906 and rs2480258) and the deletions of GSTM1 and GSTT1. Although in need of confirmation, the interactions between acrylamide intake and CYP2E1 SNPs contribute to the evidence for a causal relationship between acrylamide and endometrial cancer risk.|
|Notes: ||[Hogervorst, Janneke G. F.] Hasselt Univ, Ctr Environm Sci, Diepenbeek, Belgium. [Hogervorst, Janneke G. F.; van den Brandt, Piet A.; Schouten, Leo J.] Maastricht Univ, Sch Oncol & Dev Biol GROW, Dept Epidemiol, Maastricht, Netherlands. [Godschalk, Roger W. L.; van Schooten, Frederik-Jan] Maastricht Univ, Sch Nutr & Translat Res Metab NUTRIM, Dept Pharmacol & Toxicol, Maastricht, Netherlands.|
|ISI #: ||000392009200001|
|Type: ||Journal Contribution|
|Appears in Collections: ||Research publications|
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