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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/23270

Title: B cells of multiple sclerosis patients induce autoreactive proinflammatory T cell responses
Authors: Fraussen, Judith
Claes, Nele
Van Wijmeersch, Bart
van Horssen, Jack
Stinissen, Piet
Hupperts, Raymond
Somers, Veerle
Issue Date: 2016
Citation: CLINICAL IMMUNOLOGY, 173, p. 124-132
Abstract: Antibody-independent B cell functions play an important role in multiple sclerosis (MS) pathogenesis. In this study, B cell antigen presentation and costimulation in MS were studied. Peripheral blood B cells of MS patients showed increased expression of costimulatory CD86 and CD80 molecules compared with healthy controls (HC). In MS cerebrospinal fluid (CSF), 12-fold and 2-fold increases in CD86(+) and CD80 B cells, respectively, were evidenced compared with peripheral blood. Further, B cells from MS patients induced proinflammatory T cells in response to myelin basic protein (MBP). Immunomodulatory treatment restored B cell costimulatory molecule expression and caused significantly reduced B cell induced T cell responses. Together, these results demonstrate the potential of B cells from MS patients to induce autoreactive proinflammatory T cell responses. Immunomodulatory therapy abrogated this effect, emphasizing the importance of B cell antigen presentation and costimulation in MS pathology. (C) 2016 Elsevier Inc. All rights reserved.
Notes: [Fraussen, Judith; Claes, Nele; Van Wijmeersch, Bart; van Horssen, Jack; Stinissen, Piet; Somers, Veerle] Univ Limburg, Hasselt Univ, Sch Life Sci, Biomed Res Inst & Transnat, Diepenbeek, Belgium. [Van Wijmeersch, Bart] Revalidat & MS Ctr, Overpelt, Belgium. [van Horssen, Jack] Vrije Univ Amsterdam, Med Ctr, Dept Mol Cell Biol & Immunol, Amsterdam, Netherlands. [Hupperts, Raymond] Maastricht Univ, Sch Mental Hlth & Neurosci, Dept Neurosci, Maastricht, Netherlands. [Hupperts, Raymond] Acad MS Ctr Limburg, Zuyderland Med Centrum, Sittard, Netherlands.
URI: http://hdl.handle.net/1942/23270
DOI: 10.1016/j.clim.2016.10.001
ISI #: 000389864200017
ISSN: 1521-6616
Category: A1
Type: Journal Contribution
Appears in Collections: Research publications

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