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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/23137

Title: The Neurovascular Properties of Dental Stem Cells and Their Importance in Dental Tissue Engineering
Authors: Ratajczak, Jessica
Bronckaers, Annelies
Dillen, Yörg
Gervois, Pascal
Vangansewinkel, Tim
Driesen, Ronald
Wolfs, Esther
Lambrichts, Ivo
Hilkens, Petra
Issue Date: 2016
Citation: Stem Cells International, 2016 (Art N° 9762871)
Abstract: Within the field of tissue engineering, natural tissues are reconstructed by combining growth factors, stem cells, and different biomaterials to serve as a scaffold for novel tissue growth. As adequate vascularization and innervation are essential components for the viability of regenerated tissues, there is a high need for easily accessible stem cells that are capable of supporting these functions. Within the human tooth and its surrounding tissues, different stem cell populations can be distinguished, such as dental pulp stem cells, stem cells from human deciduous teeth, stem cells from the apical papilla, dental follicle stem cells, and periodontal ligament stem cells. Given their straightforward and relatively easy isolation from extracted third molars, dental stem cells (DSCs) have become an attractive source of mesenchymal-like stem cells. Over the past decade, there have been numerous studies supporting the angiogenic, neuroprotective, and neurotrophic effects of the DSC secretome. Together with their ability to differentiate into endothelial cells and neural cell types, this makes DSCs suitable candidates for dental tissue engineering and nerve injury repair.
URI: http://hdl.handle.net/1942/23137
DOI: 10.1155/2016/9762871
ISI #: 000383633800001
ISSN: 1687-966X
Category: A1
Type: Journal Contribution
Validation: ecoom, 2017
Appears in Collections: Research publications

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