Document Server@UHasselt >
Research >
Research publications >

Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/23132

Title: Circulating classical monocytes are associated with CD11c+ macrophages in human visceral adipose tissue
Authors: Wouters, Kristiaan
Gaens, Katrien
Bijnen, Mitchell
Verboven, Kenneth
Jocken, Johan
Wetzels, Suzan
Wijnands, Erwin
Hansen, Dominique
van Greevenbroek, Marleen
Duijvestijn, Adriaan
Biessen, Erik
Blaak, Ellen
Stehouwer, Coen
Schalkwijk, Casper
Issue Date: 2017
Citation: Scientific Reports, 7 (Art N° 42665)
Abstract: Immune cell accumulation in adipose tissue (AT) is associated with the development of AT inflammation, resulting in metabolic dysfunction. Circulating immune cell patterns may reflect immune cell accumulation in expanding AT. However, data linking human leukocytes in blood and AT is lacking. We investigated whether blood immune cell populations are associated with their counterparts in subcutaneous (scAT) or visceral AT (vAT). Flow cytometry was performed on blood, scAT and vAT from 16 lean and 29 obese men. Circulating natural killer (NK)-cells, classical monocytes and nonclassical monocytes were higher in obese individuals. vAT, but not scAT, of obese individuals contained more inflammatory CD11c+ “M1” macrophages and NK cells compared to lean individuals. Blood classical monocytes were associated with CD11c+ macrophages in vAT but not scAT. This association was unrelated to expression of the adhesion molecules CD11b and CD11c or of the chemokine receptor CX3CR1 on these monocytes. Other AT immune cells were not associated with their respective counterparts in blood. Finally, CD11c+ macrophages and CD4+ T-cells in vAT were associated with their counterparts in scAT. In conclusion, blood classical monocytes reflect CD11c+ macrophages in vAT.
Notes: Wouters, K (reprint author), Maastricht Univ, Med Ctr, Cardiovasc Res Inst Maastricht CARIM, Maastricht, Netherlands. kristiaan.wouters@maastrichtuniversity.nl
URI: http://hdl.handle.net/1942/23132
DOI: 10.1038/srep42665
ISI #: 000394253000001
ISSN: 2045-2322
Category: A1
Type: Journal Contribution
Validation: ecoom, 2018
Appears in Collections: Research publications

Files in This Item:

Description SizeFormat
Published version609.92 kBAdobe PDF

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.