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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/23091

Title: Global genotype distribution of hepatitis C viral infection among people who inject drugs
Authors: Bielen, Rob
Robaeys, Geert
Darush, Ghezel Azar
Razavi, Homie
Nevens, Frederik
Issue Date: 2016
Citation: Journal of hepatology, 65(6), p. 1094-1103
Abstract: Background and aims: Hepatitis C viral infection (HCV) after injection drug use is very prevalent. The kind of genotype determines the response to treatment. However, no systematic review update on the global genotype distribution of HCV in people who inject drugs (PWID) is available at this moment. Method: A systematic review was performed by using the keywords: Genotype, Hepatitis C, Injection drug user / Intravenous drug user / Substance user/ PWID, Name of countries in Pubmed, Embase and PsychInfo. The results were compared with the review of Gower et al. in 2014, concerning the distribution of HCV genotypes in the general HCV population. Findings: Using these keywords, 132 studies in 48 countries (from 1995 to 2015) were collected. After grading these results, the data of 48 studies were used to determine the distribution of genotypes in PWID. Genotype 1 is the most prevalent genotype all over the world in PWID. In Europe, genotypes 1, 3 and 4 are highly prevalent. In North and South America and in Australia genotype 1 and 3 are most prevalent. In Asia genotype 2 and 6, and Africa genotype 1a and 4 are mostly observed. Overall, the most important differences comparing with the general population are a lower prevalence of genotype 1b in the PWID population and higher prevalence of genotype 1a and 3. Interpretation: There is a different prevalence of genotype distribution in PWID than in the general population. Especially genotype 3 is highly prevalent in the Western countries.
URI: http://hdl.handle.net/1942/23091
DOI: 10.1016/j.jhep.2016.07.042
ISI #: 000389097700007
ISSN: 0168-8278
Category: A1
Type: Journal Contribution
Appears in Collections: Research publications

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