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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/23077

Title: Profluorescent PPV-based Micellar System as a Versatile Probe for Bioimaging and Drug Delivery
Authors: Zaquen, Neomy
Lu, Hongxu
Chang, Teddy
Mamdooh, Russel
Lutsen, Laurence
Vanderzande, Dirk
Stenzel, Martina
Junkers, Thomas
Issue Date: 2016
Citation: Biomacromolecules, 17(12), p. 4086-4094
Abstract: Although micelles are commonly used for drug delivery purposes, their long-term fate is often unknown due to photobleaching of the fluorescent labels or the use of toxic materials. Here, we present a metal-free, nontoxic, nonbleaching, fluorescent micelle that can address these shortcomings. A simple, yet versatile, profluorescent micellar system, built from amphiphilic poly(p-phenylenevinylene) (PPV) block copolymers, for use in drug delivery applications is introduced. Polymer micelles made from PPV show excellent stability for up to 1 year and are successfully loaded with anticancer drugs (curcumin or doxorubicin) without requiring introduction of physical or chemical cross-links. The micelles are taken up efficiently by the cells, which triggers disassembly, releasing the encapsulated material. Disassembly of the micelles and drug release is conveniently monitored as fluorescence of the single polymer chains appear, which enables not only to monitor the release of the payload, but in principle also the fate of the polymer over longer periods of time.
URI: http://hdl.handle.net/1942/23077
DOI: 10.1021/acs.biomac.6b01653
ISI #: 000389787200026
ISSN: 1525-7797
Category: A1
Type: Journal Contribution
Appears in Collections: Research publications

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