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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/23037

Title: Prevalence and incidence of neurological disorders among adult Ugandans in rural and urban Mukono district; a cross-sectional study
Authors: Kaddumukasa, Mark
Mugenyi, Levicatus
Kaddumukasa, Martin N.
Ddumba, Edward
Devereaux, Michael
Furlan, Anthony
Sajatovic, Martha
Katabira, Elly
Issue Date: 2016
Publisher: BIOMED CENTRAL LTD
Citation: BMC NEUROLOGY, 16 (Art N° 227)
Abstract: Background: The burden of neurological diseases is increasing in developing countries. However, there is a prominent scarcity of literature on the incidence of neurological diseases in sub-Saharan Africa. This study was therefore undertaken to determine the prevalence and incidence of neurological diseases in this setting to serve as a baseline for planning and care for neurological disorders in Uganda. Methods: The study was conducted within rural and urban Mukono district, east of Kampala city of Uganda, central region. Over a period of six months, a cross sectional survey was conducted and screening was performed using a standardized questionnaire. All subjects with neurological symptoms and signs were reviewed by a team of neurologists and neurological diagnoses made. Results: Of the 3000 study subjects, 50.3% (1510/3000) were from the rural setting. Out of the participants screened, 67.4% were female, with a median age of 33 years. Among the 98 subjects with confirmed neurological disorders, the frequency of diseases was as follows; peripheral neuropathy (46.2%), chronic headaches (26.4%), and epilepsy (8.5%), followed by pain syndromes (7.5%), stroke (6.6%) and tremors/Parkinson disease (3.8%). The crude prevalence rates of these disorders (95% CI) were 14.3% (8.5-24.1); 13.3% (7.7-22.8); 33.7% (23.9-47.4) for stroke, epilepsy and peripheral neuropathy respectively. Peripheral neuropathy followed by chronic headaches had the highest estimated incidence/1000 years. Stroke had an estimated incidence of 3.6 new cases with 95% CI of (2.1-6.1)/1000 years. Conclusion: Peripheral neuropathy, chronic headaches and epilepsy disorders are major causes of morbidity in Sub-Saharan settings. There is an urgent need of more robust and powered studies to determine the incidence of these diseases.
Notes: [Kaddumukasa, Mark; Kaddumukasa, Martin N.; Katabira, Elly] Makerere Univ, Coll Hlth Sci, Sch Med, Dept Med, POB 7072, Kampala, Uganda. [Mugenyi, Leviticus] Infect Dis Res Collaborat, Mulago Hill Rd,MUJHU3 Bldg,POB 7475, Kampala, Uganda. [Mugenyi, Leviticus] Hasselt Univ, Interuniv Inst Biostat & Stat Bioinformat, Diepenbeek, Belgium. [Ddumba, Edward] Nkozi Univ, St Raphael St Francis Nsambya Hosp, Dept Med, POB 7146, Kampala, Uganda. [Devereaux, Michael; Furlan, Anthony] Case Western Reserve Univ, Univ Hosp Case Med Ctr, Neurol Inst, 11100 Euclid Ave, Cleveland, OH 44106 USA. [Sajatovic, Martha] Univ Hosp Case Med Ctr, Neurol & Behav Outcomes Ctr, 11100 Euclid Ave, Cleveland, OH 44106 USA.
URI: http://hdl.handle.net/1942/23037
DOI: 10.1186/s12883-016-0732-y
ISI #: 000388129600005
ISSN: 1471-2377
Category: A1
Type: Journal Contribution
Validation: ecoom, 2017
Appears in Collections: Research publications

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