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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/23025

Title: Viral interference of bacterial RNA metabolism machinery
Authors: Dendooven, Tom
Van den Bossche, An
Hendrix, Hanne
Ceyssens, Pieter-Jan
Voet, Marleen
Bandyra, KJ
De Mayer, Marc
Aertsen, Abram
Noben, Jean-Paul
Hardwick Steven
Luisi, Ben
Lavigne, Rob
Issue Date: 2017
Citation: RNA Biology, 14 (1), p. 6-10
Abstract: In a recent publication, we reported a unique interaction between a protein encoded by the giant myovirus phiKZ and the Pseudomonas aeruginosa RNA degradosome. Crystallography, site-directed mutagenesis and interactomics approaches revealed this ‘degradosome interacting protein’ or Dip, to adopt an ‘open-claw’ dimeric structure that presents acidic patches on its outer surface which hijack two conserved RNA binding sites on the scaffold domain of the RNase E component of the RNA degradosome. This interaction prevents substrate RNAs from being bound and degraded by the RNA degradosome during the virus infection cycle. In this commentary, we provide a perspective into the biological role of Dip, its structural analysis and its mysterious evolutionary origin, and we suggest some therapeutic and biotechnological applications of this distinctive viral protein.
Notes: bfl20@cam.ac.uk; rob.lavigne@kuleuven.be
URI: http://hdl.handle.net/1942/23025
DOI: 10.1080/15476286.2016.1251003
ISI #: 000392612000002
ISSN: 1547-6286
Category: A1
Type: Journal Contribution
Appears in Collections: Research publications

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