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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/23001

Title: Air Pollution Stress and the Aging Phenotype: The Telomere Connection
Authors: Martens, Dries S.
Nawrot, Tim S.
Issue Date: 2016
Citation: Current Environmental Health Reports, 3(3), p. 258-269
Abstract: Aging is a complex physiological phenomenon. The question why some subjects grow old while remaining free from disease whereas others prematurely die remains largely unanswered. We focus here on the role of air pollution in biological aging. Hallmarks of aging can be grouped into three main categories: genomic instability, telomere attrition, and epigenetic alterations leading to altered mitochondrial function and cellular senescence. At birth, the initial telomere length of a person is largely determined by environmental factors. Telomere length shortens with each cell division and exposure to air pollution as well as low residential greensspace exposure is associated with shorter telomere length. Recent studies show that the estimated effects of particulate air pollution exposure on the telomere mitochondrial axis of aging may play an important role in chronic health effects of air pollution. The exposome encompasses all exposures over an entire life. As telomeres can be considered as the cellular memories of exposure to oxidative stress and inflammation, telomere maintenance may be a proxy for assessing the Bexposome^. If telomeres are causally related to the aging phenotype and environmental air pollution is an important determinant of telomere length, this might provide new avenues for future preventive strategies.
URI: http://hdl.handle.net/1942/23001
DOI: 10.1007/s40572-016-0098-8
ISSN: 2196-5412
Category: A2
Type: Journal Contribution
Appears in Collections: Research publications

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