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Title: Stem Cell-Based Therapies for Ischemic Stroke: Preclinical Results and the Potential of Imaging-Assisted Evaluation of Donor Cell Fate and Mechanisms of Brain Regeneration
Authors: Gervois, Pascal
Wolfs, Esther
Ratajczak, Jessica
Dillen, Yörg
Vangansewinkel, Tim
Hilkens, Petra
Bronckaers, Annelies
Lambrichts, Ivo
Struys, Tom
Issue Date: 2016
Citation: MEDICINAL RESEARCH REVIEWS, 36(6), p. 1080-1126
Abstract: Stroke is the second most common cause of death and is a major cause of permanent disability. Given the current demographic trend of an ageing population and associated increased risk, the prevalence of and socioeconomic burden caused by stroke will continue to rise. Current therapies are unable to sufficiently ameliorate the disease outcome and are not applicable to all patients. Therefore, strategies such as cell-based therapies with mesenchymal stem cell (MSC) or induced pluripotent stem cell (iPSC) pave the way for new treatment options for stroke. These cells showed great preclinical promise despite the fact that the precise mechanism of action and the optimal administration route are unknown. To gain dynamic insights into the underlying repair processes after stem cell engraftment, noninvasive imaging modalities were developed to provide detailed spatial and functional information on the donor cell fate and host microenvironment. This review will focus on MSCs and iPSCs as types of widely used stem cell sources in current (bio)medical research and compare their efficacy and potential to ameliorate the disease outcome in animal stroke models. In addition, novel noninvasive imaging strategies allowing temporospatial in vivo tracking of transplanted cells and coinciding evaluation of neuronal repair following stroke will be discussed.
Notes: Struys, T (reprint author), Hasselt Univ, Biomed Res Inst, Morphol Res Grp, Campus Diepenbeek, Diepenbeek, Belgium. tom.struys@uhasselt.be
URI: http://hdl.handle.net/1942/22909
DOI: 10.1002/med.21400
ISI #: 000386803100003
ISSN: 0198-6325
Category: A1
Type: Journal Contribution
Validation: ecoom, 2017
Appears in Collections: Research publications

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