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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/22882

Title: Associations between Measures of Structural Morphometry and Sensorimotor Performance in Individuals with Nonspecific Low Back Pain
Authors: Caeyenberghs, Karen
Pijnenburg, Madelon
Goossens, Nina
Janssens, Lotte
Brumagne, Simon
Issue Date: 2016
Citation: American journal of neuroradiology, 38 (1), pag. 183-191
Status: In Press
Abstract: BACKGROUND AND PURPOSE: To date, most structural brain imaging studies in individuals with nonspecific low back pain have evaluated volumetric changes. These alterations are particularly found in sensorimotor-related areas. Although it is suggested that specific measures, such as cortical surface area and cortical thickness, reflect different underlying neural architectures, the literature regarding these different measures in individuals with nonspecific low back pain is limited. Therefore, the current study was designed to investigate the association between the performance on a sensorimotor task, more specifically the sit-to-stand-to-sit task, and cortical surface area and cortical thickness in individuals with nonspecific low back pain and healthy controls. MATERIALS AND METHODS: Seventeen individuals with nonspecific low back pain and 17 healthy controls were instructed to perform 5 consecutive sit-to-stand-to-sit movements as fast as possible. In addition, T1-weighted anatomic scans of the brain were acquired and analyzed with FreeSurfer. RESULTS: Compared with healthy controls, individuals with nonspecific low back pain needed significantly more time to perform sit-to-stand-to-sit movements (P .05). Brain morphometric analyses revealed that cortical thickness of the ventrolateral prefrontal cortical regions was increased in patients with nonspecific low back pain compared with controls. Furthermore, decreased cortical thickness of the rostral anterior cingulate cortex was associated with lower sit-to-stand-to-sit performance on an unstable support surface in individuals with nonspecific low back pain and healthy controls (r 0.47, P .007). In addition, a positive correlation was found between perceived pain intensity and cortical thickness of the superior frontal gyrus (r0.70, P.002) and the pars opercularis of the inferior ventrolateral prefrontal cortex (r 0.67, P .004). Hence, increased cortical thickness was associated with increased levels of pain intensity in individuals with nonspecific low back pain. No associations were found between cortical surface area and the pain characteristics in this group. CONCLUSIONS: The current study suggests that cortical thickness may contribute to different aspects of sit-to-stand-to-sit performance and perceived pain intensity in individuals with nonspecific low back pain.
Notes: Pijnenburg, M (reprint author), Univ Leuven, Katholieke Univ Leuven, Fac Kinesiol & Rehabil Sci, Dept Rehabil Sci,Res Grp Musculoskeletal Rehabil, Tervuursevest 101,Bus 1501, B-3001 Leuven, Belgium. m.pijnenburg@fontys.nl
URI: http://hdl.handle.net/1942/22882
DOI: 10.3174/ajnr.A5020
ISI #: 000392163600029
ISSN: 0195-6108
Category: A1
Type: Journal Contribution
Appears in Collections: Research publications

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