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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/22847

Title: Redox-Related Mechanisms to Rebalance Cancer-Deregulated Cell Growth
Authors: Stevens, An-Sofie
Pirotte, Nicky
Wouters, Annelies
Van Roten, Andromeda
Van Belleghem, Frank
Willems, Maxime
Cuypers, Ann
Artois, Tom
Smeets, Karen
Issue Date: 2016
Citation: CURRENT DRUG TARGETS, 17(12), p. 1414-1437
Abstract: A delicate balance exists between the process of carcinogenesis and tissue regeneration. A number of malignant tumours are considered the outcome of an impaired or incomplete regeneration process, resulting in persistently dividing cells. Regeneration-competent tissues and animals are able to prevent and counteract growth abnormalities and seem to have a low vulnerability to chemical carcinogenesis. Cancer cell survival depends, among other things, on various redox-related mechanisms, which are targets of currently developed therapies. Disadvantages of these therapies are a lack of specificity and drug resistance. As the majority of these redox-related mechanisms also play an important role in successful and coordinated cell functioning and reproduction, the regeneration process offers a unique parallel context for modern cancer research. This review focuses on the interconnections between regeneration and carcinogenesis and how an understanding of regenerative forces and redox-controlled mechanisms could contribute to the identification of new therapeutic targets to block the growth and survival of cancer cells.
Notes: [Stevens, An-Sofie; Pirotte, Nicky; Wouters, Annelies; Van Roten, Andromeda; Van Belleghem, Frank; Cuypers, Ann; Artois, Tom; Smeets, Karen] Hasselt Univ, Ctr Environm Sci, Agoralaan,Bldg D, B-3590 Diepenbeek, Belgium. [Van Belleghem, Frank] Open Univ, Fac Management Sci & Technol, Valkenburgweg 177, Heerlen, Netherlands;. [Willems, Maxime] Univ Ghent, Fac Pharmaceut Sci, Lab Pharmaceut Technol, B-9000 Ghent, Belgium. [Willems, Maxime] Univ Ghent, Lab Environm Toxicol & Aquat Ecol, Jozef Plateaustr 22, B-9000 Ghent, Belgium.
URI: http://hdl.handle.net/1942/22847
DOI: 10.2174/1389450116666150506112817
ISI #: 000387082600006
ISSN: 1389-4501
Category: A1
Type: Journal Contribution
Validation: ecoom, 2017
Appears in Collections: Research publications

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