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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/22827

Title: The molecular biology of matrix metalloproteinases and tissue inhibitors of metalloproteinases in inflammatory bowel diseases
Authors: de Bruyn, Magali
Vandooren, Jennifer
Ugarte-Berzal, Estefania
Arijs, Ingrid
Vermeire, Severine
Opdenakker, Ghislain
Issue Date: 2016
Abstract: Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) are thought to be predominant proteases and protease inhibitors involved in the pathogenesis of inflammatory bowel diseases (IBD) through their ability to remodel the extracellular matrix (ECM) in response to inflammatory stimuli and by their immunomodulating effects. An imbalance between MMPs and TIMPs has been linked with acute and chronic inflammation and aberrant tissue remodeling, as seen in IBD. Moreover, recurrent phases of tissue destruction and subsequent tissue repair can cause serious complications in IBD patients such as fistulas and fibrosis. The aims of this review are (i) to summarize current literature on genetic association, mRNA, and protein expression studies with regard to MMPs and TIMPs in IBD patients and various animal models, including those with transgenic and knockout mice; (ii) to compare biochemical and molecular biological data in humans with those obtained in animal model studies and (iii) to critically evaluate and translate how this knowledge may be used in practical terms to understand better the pathophysiology and mechanisms operating in IBD and to apply this for improvement of clinical outcomes at diagnostic, prognostic and therapeutic levels.
Notes: [de Bruyn, Magali; Vandooren, Jennifer; Ugarte-Berzal, Estefania; Opdenakker, Ghislain] Katholieke Univ Leuven, Rega Inst Med Res, Dept Microbiol & Immunol, Immunobiol Lab, Minderbroedersstr 10 Blok 10 Bus 1030, Leuven, Belgium. [de Bruyn, Magali; Arijs, Ingrid; Vermeire, Severine] Katholieke Univ Leuven, Dept Clin & Expt Med, Translat Res Ctr Gastrointestinal Disorders TARGI, Leuven, Belgium. [Arijs, Ingrid] Hasselt Univ, Fac Med & Life Sci, Hasselt, Belgium. [Vermeire, Severine] Univ Hosp Leuven, Leuven, Belgium.
URI: http://hdl.handle.net/1942/22827
DOI: 10.1080/10409238.2016.1199535
ISI #: 000387059200001
ISSN: 1040-9238
Category: A1
Type: Journal Contribution
Validation: ecoom, 2017
Appears in Collections: Research publications

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