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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/22787

Title: Proteomics applications in Caenorhabditis elegans research
Authors: Husson, Steven J.
Moyson, Sofie
Valkenborg, Dirk
Baggerman, Geert
Mertens, Inge
Issue Date: 2015
Abstract: The free-living nematode Caenorhabditis elegans is one of the most studied models in a wide variety of research fields with applications in agro- or pharmaceutical industries. It has been used for the development of new anthelminthic drugs and was proven to yield key insights in neurodegenerative diseases and metabolic syndromes. Due to its suitability for high-throughput genetic screens, efficiency for RNA interference approaches and the availability of thousands of mutants, most studies were carried out at the genetic level. However, determining the cellular function of each gene product remains an unfinished goal in this post-genomic era. A systems biology approach focusing on the actual gene products (i.e. proteins) can help unraveling this puzzle. A fundamental pillar in this research is mass spectrometry-based proteomics. We here provide an in-depth overview of proteomics-related studies in C. elegans research, with special emphasis on the methodologies and biological applications.
URI: http://hdl.handle.net/1942/22787
DOI: 10.1016/j.bbrc.2015.11.026
ISI #: 000367868500001
ISSN: 0006-291X
Category: A1
Type: Journal Contribution
Validation: ecoom, 2017
Appears in Collections: Research publications

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