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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/22750

Title: Metabolic targets of endocrine disrupting chemicals assessed by cord blood transcriptome profiling
Authors: Remy, Sylvie
Govarts, Eva
Wens, Britt
De Boever, Patrick
Den Hond, Elly
Croes, Kim
Sioen, Isabelle
Baeyens, Willy
van Larebeke, Nicolas
Koppe, Janna
Covaci, Adrian
Schettgen, Thomas
Nelen, Vera
Legler, Juliette
Schoeters, Greet
Issue Date: 2016
Citation: REPRODUCTIVE TOXICOLOGY, 65, p. 307-320
Abstract: Early life exposure to endocrine disrupting chemicals (EDCs) has been frequently associated with impaired perinatal growth, an important risk factor for later onset of metabolic disorders. We analyzed whether the cord blood transcriptome showed early indications of alterations in metabolic processes in 195 human samples in relation to cord blood levels of dichlorodiphenyldichloroethylene (p,p'-DDE), polychlorinated biphenyl-153 (PCB-153), perfluorooctanoic acid (PFOA), and perfluorooctane sulfonate (PFOS). Overall, 39 metabolically relevant transcription factors were significantly enriched (31 by p,p'-DDE, 10 by PCB-153, 8 by PFOA, and 2 by PFOS). These included the glucocorticoid receptor (p,p'-DDE and PCB-153) and the progesterone receptor (PFOA and PFOS). The 'insulin receptor signaling', 'acute phase response signaling', 'Interleukin(IL)-6 signaling', and 'prolactin signaling' pathways were significantly enriched in relation to p,p'-DDE. Transcriptional changes at birth suggest a role for specific metabolic targets as a link between prenatal EDC exposure and metabolic disorders later in life. (C) 2016 Elsevier Inc. All rights reserved.
Notes: [Remy, Sylvie] Univ Antwerp, Epidemiol & Social Med, Univ Pl 1, B-2610 Antwerp, Belgium. [Remy, Sylvie; Govarts, Eva; Wens, Britt; De Boever, Patrick; Den Hond, Elly; Schoeters, Greet] Flemish Inst Technol Res VITO, Environm Risk & Hlth, Boeretang 200, B-2400 Mol, Belgium. [De Boever, Patrick] Hasselt Univ, Ctr Environm Sci, Agoralaan Gebouw D, B-3590 Diepenbeek, Belgium. [Den Hond, Elly] Sci Inst Publ Hlth, Directorate Publ Hlth & Surveillance, Juliette Wytsmanstr 14, B-1050 Brussels, Belgium. [Croes, Kim; Baeyens, Willy; van Larebeke, Nicolas] Vrije Univ Brussel, Dept Analyt Environm & Geochem AEGC, Pl Laan 2, B-1050 Brussels, Belgium. [Sioen, Isabelle] Univ Ghent, Dept Publ Hlth, St Pietersnieuwstr 33, B-9000 Ghent, Belgium. [Sioen, Isabelle] FWO Res Fdn, Egmontstr 5, B-1000 Brussels, Belgium. [van Larebeke, Nicolas] Univ Ghent, Dept Radiotherapy & Expt Canc Res, St Pietersnieuwstr 33, B-9000 Ghent, Belgium. [Koppe, Janna] Univ Amsterdam, EKZ AMC, De Boelelaan 1105, NL-1081 HV Amsterdam, Netherlands. [Covaci, Adrian] Univ Antwerp, Toxicol Ctr, Univ Pl 1, B-2610 Antwerp, Belgium. [Schettgen, Thomas] Rhein Westfal TH Aachen, Fac Med, Inst Occupat & Social Med, Pauwelsstr 30, D-52074 Aachen, Germany. [Nelen, Vera] Prov Inst Hyg, Dept Hlth, Kronenburgstr 45, B-2000 Antwerp, Belgium. [Legler, Juliette] Vrije Univ Amsterdam, Inst Environm Studies, De Boelelaan 1105, NL-1081 HV Amsterdam, Netherlands. [Schoeters, Greet] Univ Antwerp, Biomed Sci, Univ Pl 1, B-2610 Antwerp, Belgium. [Schoeters, Greet] Univ Southern Denmark, Environm Med, Campusvej 55, DK-5000 Odense, Denmark.
URI: http://hdl.handle.net/1942/22750
DOI: 10.1016/j.reprotox.2016.08.018
ISI #: 000385990900034
ISSN: 0890-6238
Category: A1
Type: Journal Contribution
Validation: ecoom, 2017
Appears in Collections: Research publications

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