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|Title: ||Transcutaneous carbon-dioxide partial pressure trends during six-minute walk test in patients with very severe COPD|
|Authors: ||Andrianopoulos, Vasileios|
Vanfleteren, Lowie E. G. W.
Wouters, Emiel F. M.
Spruit, Martijn A.
|Issue Date: ||2016|
|Publisher: ||ELSEVIER SCIENCE BV|
|Citation: ||RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY, 233, p. 52-59|
|Abstract: ||Background: Transcutaneous carbon-dioxide partial-pressure (TCPCO2) can be reliably measured and may be of clinical relevance in COPD. Changes in TCPCO2 and exercise-induced hypercapnia (EIH) during six-minute walk test (6MWT) need further investigation. We aimed (1) to define patterns of TCPCO2 trends during 6MWT and (2) to study determinants of CO2-retention and EIH. Methods: Sixty-two COPD patients (age: 63 +/- 8years, FEV1: 33 +/- 10%pred.) were recruited and T(C)PCO2 was recorded by SenTec digital-monitoring-system during 6MWT. Results: Half of patients (50%) exhibited CO2-retention (TCPCO2 [Delta] >4 mmHg); 26% preserved and 24% reduced TCPCO2. Nineteen (31%) patients presented EIH (TCPCO2 >45 mmHg). EIH was associated to higher baseline-PCCO2, worse FEV1, lower inspiratory-pressures, underweight/normal BMI, and pre-walk dyspnea. Stronger determinants of CO2-retention were FEV1 and pre-walk dyspnea, whereas baseline-PCCO2 and pre-walk dyspnea better predict EIH. Conclusions: PCO2 response to 6MWT is highly heterogeneous; however, very low FEV1 and elevated baseline-PCCO2 together with pre-walk dyspnea increase the risk for CO2-retention and EIH. Overweight-BMI seems to carry a protective effect against EIH in very severe COPD. (C) 2016 Elsevier B.V. All rights reserved.|
|Notes: ||[Andrianopoulos, Vasileios; Vanfleteren, Lowie E. G. W.; Wouters, Emiel F. M.; Spruit, Martijn A.] Ctr Expertise Chron Organ Failure, CIRO, Dept Res & Educ, Horn, Netherlands. [Andrianopoulos, Vasileios; Jarosch, Inga; Gloeckl, Rainer; Schneeberger, Tessa; Kenn, Klaus] Schoen Klin Berchtesgadener Land, Dept Resp Med & Pulm Rehabil, Schoenau, Germany. [Vanfleteren, Lowie E. G. W.; Wouters, Emiel F. M.] Maastricht Univ, Med Ctr MUMC, Dept Resp Med, Maastricht, Netherlands. [Gloeckl, Rainer] Tech Univ Munich, Klinikum Rechts Isar, Dept Prevent Rehabil & Sports Med, Munich, Germany. [Schneeberger, Tessa; Kenn, Klaus] Univ Marburg, Dept Pulm Rehabil, Marburg, Germany. [Spruit, Martijn A.] Hasselt Univ, BIOMED Biomed Res Inst, Fac Med & Life Sci, REVAL Rehabil Res Ctr, Diepenbeek, Belgium.|
|ISI #: ||000386410600008|
|Type: ||Journal Contribution|
|Validation: ||ecoom, 2017|
|Appears in Collections: ||Research publications|
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