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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/22726

Title: Interactions of Aqueous Imidazolium-Based Ionic Liquid Mixtures with Solid-Supported Phospholipid Vesicles
Authors: Losada-Pérez, Patricia
Khorshid, Mehran
Renner, Frank Uwe
Issue Date: 2016
Publisher: PUBLIC LIBRARY SCIENCE
Citation: PLOS ONE, 11(9) (Art N° e0163518)
Abstract: Despite the environmentally friendly reputation of ionic liquids (ILs), their safety has been recently questioned given their potential as cytotoxic agents. The fundamental mechanisms underlying the interactions between ILs and cells are less studied and by far not completely understood. Biomimetic films are here important biophysical model systems to elucidate fundamental aspects and mechanisms relevant for a large range of biological interaction ranging from signaling to drug reception or toxicity. Here we use dissipative quartz crystal microbalance QCM-D to examine the effect of aqueous imidazolium-based ionic liquid mixtures on solid-supported biomimetic membranes. Specifically, we assess in real time the effect of the cation chain length and the anion nature on a supported vesicle layer of the model phospholipid DMPC. Results indicate that interactions are mainly driven by the hydrophobic components of the IL, which significantly distort the layer and promote vesicle rupture. Our analyses evidence the gradual decrease of the main phase transition temperature upon increasing IL concentration, reflecting increased disorder by weakening of lipid chain interactions. The degree of rupture is significant for ILs with long hydrophobic cation chains and large hydrophobic anions whose behavior is reminiscent of that of antimicrobial peptides.
Notes: [Losada-Perez, Patricia; Khorshid, Mehran; Renner, Frank Uwe] Hasselt Univ, Inst Mat Res IMO, Diepenbeek, Belgium. [Renner, Frank Uwe] IMEC VZW, Associated Lab IMOMEC, Diepenbeek, Belgium.
URI: http://hdl.handle.net/1942/22726
DOI: 10.1371/journal.pone.0163518
ISI #: 000384328500066
ISSN: 1932-6203
Category: A1
Type: Journal Contribution
Validation: ecoom, 2017
Appears in Collections: Research publications

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