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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/22698

Title: Muscular, cardiac, ventilatory and metabolic dysfunction in patients with multiple sclerosis: Implications for screening, clinical care and endurance and resistance exercise therapy, a scoping review
Authors: Wens, Inez
Eijnde, Bert O.
Hansen, Dominique
Issue Date: 2016
Publisher: ELSEVIER SCIENCE BV
Citation: JOURNAL OF THE NEUROLOGICAL SCIENCES, 367, p. 107-121
Abstract: In the treatment of multiple sclerosis (MS), exercise training is now considered a cornerstone. However, most clinicians tend to focus on neurologic deficits only, and thus prefer to prescribe rehabilitation programs specifically to counteract these deficits. However, the present comprehensive review shows that patients with MS (pwMS) also experience significant muscular, cardiac, ventilatory and metabolic dysfunction, which significantly contribute, next to neurologic deficits, to exercise intolerance. In addition, these anomalies also might increase the risk for frequent hospitalization and morbidity and can reduce life expectancy. Unfortunately, the impact of exercise intervention on these anomalies in pwMS are mostly unknown. Therefore, it is suggested that pwMS should be screened systematically for muscular, cardiac, ventilatory and metabolic function during exercise testing. The detection of such anomalies should lead to adaptations and optimisation of exercise training prescription and clinical care/medical treatment of pwMS. In addition, future studies should focus on the impact of exercise intervention on muscular, cardiac, ventilatory and metabolic (dys)function in pwMS, to contribute to improved treatment and care. (C) 2016 Elsevier B.V. All rights reserved.
Notes: [Wens, Inez; Eijnde, Bert O.; Hansen, Dominique] Hasselt Univ, Fac Med & Life Sci, BIOMED Biomed Res Ctr, REVAL Rehabil Res Ctr, Diepenbeek, Belgium. [Hansen, Dominique] Jessa Hosp, Heart Ctr Hasselt, Hasselt, Belgium.
URI: http://hdl.handle.net/1942/22698
DOI: 10.1016/j.jns.2016.05.050
ISI #: 000381167600022
ISSN: 0022-510X
Category: A1
Type: Journal Contribution
Validation: ecoom, 2017
Appears in Collections: Research publications

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