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Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/22593

Title: PPV-Based Conjugated Polymer Nanoparticles as a Versatile Bioimaging Probe: A Closer Look at the Inherent Optical Properties and Nanoparticle–Cell Interactions
Authors: Peters, Martijn
Zaquen, Neomy
D'Olieslaeger, Lien
Bove, Hannelore
Vanderzande, Dirk J. M.
Hellings, Niels
Junkers, Tanja
Ethirajan, Anitha
Issue Date: 2016
Publisher: AMER CHEMICAL SOC
Citation: BIOMACROMOLECULES, 17(8), p. 2562-2571
Abstract: Conjugated polymers have attracted significant interest in the bioimaging field due to their excellent optical properties and biocompatibility. Tailor-made poly(p-phenylenevinylene) (PPV) conjugated polymer nanoparticles (NPs) are in here described. Two different nanopartide systems using poly[2-methoxy-5-(3',7'-dimethoxyoctyloxy)-1,4-phenylenevinylene](MDMO-PPV) and a functional statistical copolymer 2-(5'methoxycarbonylpentyloxy) -5-m e th oxy- 1,4-ph enyl en evinyl e n e (CPM-MDMO-PPV), containing ester groups on the alkoxy side chains, were synthesized by combining miniemulsion and solvent evaporation processes. The hydrolysis of ester groups into carboxylic acid groups on the CPM-MDMO-PPV NPs surface allows for biomolecule conjugation. The NPs exhibited excellent optical properties with a high fluorescent brightness and photostability. The NPs were in vitro tested as potential fluorescent nanoprobes for studying cell populations within the central nervous system. The cell studies demonstrated biocompatibility and surface charge dependent cellular uptake of the NPs. This study highlights that PPV-derivative based particles are a promising bioimaging probe and can cater potential applications in the field of nanomedicine.
Notes: [Peters, Martijn; Zaquen, Neomy; D'Olieslaeger, Lien; Vanderzande, Dirk; Junkers, Thomas; Ethirajan, Anitha] Hasselt Univ, Inst Mat Res, Martelarenlaan 42, B-3500 Hasselt, Belgium. [Vanderzande, Dirk; Junkers, Thomas; Ethirajan, Anitha] Imec Associated Lab IMOMEC, Wetenschapspk 1, B-3590 Diepenbeek, Belgium. [Bove, Hannelore] Hasselt Univ, Biomed Res Inst, Biophys, Agoralaan Bldg C, B-3590 Diepenbeek, Belgium. [Hellings, Niels] Hasselt Univ, Biomed Res Inst, Immunol Biochem, Agoralaan Bldg C, B-3590 Diepenbeek, Belgium.
URI: http://hdl.handle.net/1942/22593
DOI: 10.1021/acs.biomac.6b00574
ISI #: 000381231600007
ISSN: 1525-7797
Category: A1
Type: Journal Contribution
Validation: ecoom, 2017
Appears in Collections: Research publications

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